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The associations between low abundance of Mycoplasma hominis and female fecundability: a pregnancy-planning cohort study
OBJECTIVE: To explore the impact of pre-pregnancy vaginal Mycoplasma hominis (M. hominis) colonization of low abundance on female fecundability. METHODS: In total, 89 females participating in a pre-pregnancy health examination program were included, and their pregnancy outcomes were followed up for...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069813/ https://www.ncbi.nlm.nih.gov/pubmed/35513786 http://dx.doi.org/10.1186/s12866-022-02545-7 |
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author | Hong, Xiang Yin, Jiechen Wang, Wei Zhao, Fanqi Ding, Xiaoling Yu, Hong Zhang, Xuening Wang, Bei |
author_facet | Hong, Xiang Yin, Jiechen Wang, Wei Zhao, Fanqi Ding, Xiaoling Yu, Hong Zhang, Xuening Wang, Bei |
author_sort | Hong, Xiang |
collection | PubMed |
description | OBJECTIVE: To explore the impact of pre-pregnancy vaginal Mycoplasma hominis (M. hominis) colonization of low abundance on female fecundability. METHODS: In total, 89 females participating in a pre-pregnancy health examination program were included, and their pregnancy outcomes were followed up for 1 year. Vaginal swabs were collected, 16S rRNA genes were sequenced, and M. hominis colonization was confirmed by qPCR. Cox models were used to estimate the fecundability odds ratio (FOR) for women with M. hominis. RESULTS: The prevalence of M. hominis was 22.47% (20/89), and the abundance was relatively low (the cycle thresholds of the qPCR were all more than 25). In terms of the vaginal microbiome, the Simpson index of the positive group was significantly lower than that of the negative group (P = 0.003), which means that the microbiome diversity appeared to increase with M. hominis positivity. The relative abundance of M. hominis was negatively correlated with Lactobacillus crispatus (rho = − 0.24, P = 0.024), but positively correlated with Gardnerella vaginalis, Atopobium vaginae and Prevotella bivia (P all < 0.05). The cumulative one-year pregnancy rate for the M. hominis positive group was lower than that in the negative group (58.96% vs 66.76%, log-rank test: P = 0.029). After controlling for potential confounders, the risk of pregnancy in the M. hominis positive group was reduced by 38% when compared with the positive group (FOR = 0.62, 95% CI: 0.42–0.93). CONCLUSION: The vaginal colonization of M. hominis at a low level in pre-pregnant women is negatively correlated with female fecundability. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12866-022-02545-7. |
format | Online Article Text |
id | pubmed-9069813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-90698132022-05-05 The associations between low abundance of Mycoplasma hominis and female fecundability: a pregnancy-planning cohort study Hong, Xiang Yin, Jiechen Wang, Wei Zhao, Fanqi Ding, Xiaoling Yu, Hong Zhang, Xuening Wang, Bei BMC Microbiol Research OBJECTIVE: To explore the impact of pre-pregnancy vaginal Mycoplasma hominis (M. hominis) colonization of low abundance on female fecundability. METHODS: In total, 89 females participating in a pre-pregnancy health examination program were included, and their pregnancy outcomes were followed up for 1 year. Vaginal swabs were collected, 16S rRNA genes were sequenced, and M. hominis colonization was confirmed by qPCR. Cox models were used to estimate the fecundability odds ratio (FOR) for women with M. hominis. RESULTS: The prevalence of M. hominis was 22.47% (20/89), and the abundance was relatively low (the cycle thresholds of the qPCR were all more than 25). In terms of the vaginal microbiome, the Simpson index of the positive group was significantly lower than that of the negative group (P = 0.003), which means that the microbiome diversity appeared to increase with M. hominis positivity. The relative abundance of M. hominis was negatively correlated with Lactobacillus crispatus (rho = − 0.24, P = 0.024), but positively correlated with Gardnerella vaginalis, Atopobium vaginae and Prevotella bivia (P all < 0.05). The cumulative one-year pregnancy rate for the M. hominis positive group was lower than that in the negative group (58.96% vs 66.76%, log-rank test: P = 0.029). After controlling for potential confounders, the risk of pregnancy in the M. hominis positive group was reduced by 38% when compared with the positive group (FOR = 0.62, 95% CI: 0.42–0.93). CONCLUSION: The vaginal colonization of M. hominis at a low level in pre-pregnant women is negatively correlated with female fecundability. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12866-022-02545-7. BioMed Central 2022-05-05 /pmc/articles/PMC9069813/ /pubmed/35513786 http://dx.doi.org/10.1186/s12866-022-02545-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Hong, Xiang Yin, Jiechen Wang, Wei Zhao, Fanqi Ding, Xiaoling Yu, Hong Zhang, Xuening Wang, Bei The associations between low abundance of Mycoplasma hominis and female fecundability: a pregnancy-planning cohort study |
title | The associations between low abundance of Mycoplasma hominis and female fecundability: a pregnancy-planning cohort study |
title_full | The associations between low abundance of Mycoplasma hominis and female fecundability: a pregnancy-planning cohort study |
title_fullStr | The associations between low abundance of Mycoplasma hominis and female fecundability: a pregnancy-planning cohort study |
title_full_unstemmed | The associations between low abundance of Mycoplasma hominis and female fecundability: a pregnancy-planning cohort study |
title_short | The associations between low abundance of Mycoplasma hominis and female fecundability: a pregnancy-planning cohort study |
title_sort | associations between low abundance of mycoplasma hominis and female fecundability: a pregnancy-planning cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069813/ https://www.ncbi.nlm.nih.gov/pubmed/35513786 http://dx.doi.org/10.1186/s12866-022-02545-7 |
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