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A new HPLC-UV derivatization approach for the determination of potential genotoxic benzyl halides in drug substances

Benzyl halides, widely used as alkylation reagents in drug synthesis, are potential genotoxic impurities (PGTIs) required to be controlled at trace levels. However, the existing analytical methods for benzyl halides often suffer from matrix interferences or low derivatization efficiency of benzyl ch...

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Detalles Bibliográficos
Autores principales:	Ji, Shunli, Gao, Hongbin, Xia, Xingya, Zheng, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070045/ https://www.ncbi.nlm.nih.gov/pubmed/35530063 http://dx.doi.org/10.1039/c9ra03835c

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