Effect of weekly versus daily primaquine on Plasmodium vivax malaria recurrences: A real-life cohort study

BACKGROUND: Although primaquine (PQ) is indicated for G6PD-deficient patients, data on weekly PQ use in Brazil are limited. METHODS: We aimed to investigate malaria recurrences among participants receiving daily and weekly PQ treatments in a real-life setting of two municipalities in the Amazon betw...

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Autores principales: Brito-Sousa, Jose Diego, Phanor, Jeffe, Balieiro, Patricia Carvalho da Silva, Silva-Neto, Alexandre Vilhena, Cordeiro, Jady Shayenne Mota, Vitor-Silva, Sheila, Mendes, Maxwell, Sampaio, Vanderson Souza, de Melo, Gisely Cardoso, Lacerda, Marcus, Monteiro, Wuelton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070075/
https://www.ncbi.nlm.nih.gov/pubmed/35522815
http://dx.doi.org/10.1590/0037-8682-0738-2021
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author Brito-Sousa, Jose Diego
Phanor, Jeffe
Balieiro, Patricia Carvalho da Silva
Silva-Neto, Alexandre Vilhena
Cordeiro, Jady Shayenne Mota
Vitor-Silva, Sheila
Mendes, Maxwell
Sampaio, Vanderson Souza
de Melo, Gisely Cardoso
Lacerda, Marcus
Monteiro, Wuelton
author_facet Brito-Sousa, Jose Diego
Phanor, Jeffe
Balieiro, Patricia Carvalho da Silva
Silva-Neto, Alexandre Vilhena
Cordeiro, Jady Shayenne Mota
Vitor-Silva, Sheila
Mendes, Maxwell
Sampaio, Vanderson Souza
de Melo, Gisely Cardoso
Lacerda, Marcus
Monteiro, Wuelton
author_sort Brito-Sousa, Jose Diego
collection PubMed
description BACKGROUND: Although primaquine (PQ) is indicated for G6PD-deficient patients, data on weekly PQ use in Brazil are limited. METHODS: We aimed to investigate malaria recurrences among participants receiving daily and weekly PQ treatments in a real-life setting of two municipalities in the Amazon between 2019 and 2020. RESULTS: Patients receiving weekly PQ treatment had a lower risk of recurrence than those receiving daily PQ treatment (risk ratio: 0.62, 95% confidence interval: 0.41-0.94), using a model adjusted for study site. CONCLUSIONS: Weekly PQ use did not increase the risk of malaria recurrence. Further studies with larger populations are warranted.
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spelling pubmed-90700752022-05-13 Effect of weekly versus daily primaquine on Plasmodium vivax malaria recurrences: A real-life cohort study Brito-Sousa, Jose Diego Phanor, Jeffe Balieiro, Patricia Carvalho da Silva Silva-Neto, Alexandre Vilhena Cordeiro, Jady Shayenne Mota Vitor-Silva, Sheila Mendes, Maxwell Sampaio, Vanderson Souza de Melo, Gisely Cardoso Lacerda, Marcus Monteiro, Wuelton Rev Soc Bras Med Trop Short Communication BACKGROUND: Although primaquine (PQ) is indicated for G6PD-deficient patients, data on weekly PQ use in Brazil are limited. METHODS: We aimed to investigate malaria recurrences among participants receiving daily and weekly PQ treatments in a real-life setting of two municipalities in the Amazon between 2019 and 2020. RESULTS: Patients receiving weekly PQ treatment had a lower risk of recurrence than those receiving daily PQ treatment (risk ratio: 0.62, 95% confidence interval: 0.41-0.94), using a model adjusted for study site. CONCLUSIONS: Weekly PQ use did not increase the risk of malaria recurrence. Further studies with larger populations are warranted. Sociedade Brasileira de Medicina Tropical - SBMT 2022-04-29 /pmc/articles/PMC9070075/ /pubmed/35522815 http://dx.doi.org/10.1590/0037-8682-0738-2021 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Brito-Sousa, Jose Diego
Phanor, Jeffe
Balieiro, Patricia Carvalho da Silva
Silva-Neto, Alexandre Vilhena
Cordeiro, Jady Shayenne Mota
Vitor-Silva, Sheila
Mendes, Maxwell
Sampaio, Vanderson Souza
de Melo, Gisely Cardoso
Lacerda, Marcus
Monteiro, Wuelton
Effect of weekly versus daily primaquine on Plasmodium vivax malaria recurrences: A real-life cohort study
title Effect of weekly versus daily primaquine on Plasmodium vivax malaria recurrences: A real-life cohort study
title_full Effect of weekly versus daily primaquine on Plasmodium vivax malaria recurrences: A real-life cohort study
title_fullStr Effect of weekly versus daily primaquine on Plasmodium vivax malaria recurrences: A real-life cohort study
title_full_unstemmed Effect of weekly versus daily primaquine on Plasmodium vivax malaria recurrences: A real-life cohort study
title_short Effect of weekly versus daily primaquine on Plasmodium vivax malaria recurrences: A real-life cohort study
title_sort effect of weekly versus daily primaquine on plasmodium vivax malaria recurrences: a real-life cohort study
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070075/
https://www.ncbi.nlm.nih.gov/pubmed/35522815
http://dx.doi.org/10.1590/0037-8682-0738-2021
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