Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic

In this issue of JEM, Bastard et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20220028) show that a loss-of-function IFNAR1 allele is common in western Polynesians, while Duncan et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212427) report that a loss-of-function IFNAR2 allele is co...

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Autor principal: Meyts, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070088/
https://www.ncbi.nlm.nih.gov/pubmed/35486090
http://dx.doi.org/10.1084/jem.20220491
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author Meyts, Isabelle
author_facet Meyts, Isabelle
author_sort Meyts, Isabelle
collection PubMed
description In this issue of JEM, Bastard et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20220028) show that a loss-of-function IFNAR1 allele is common in western Polynesians, while Duncan et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212427) report that a loss-of-function IFNAR2 allele is common in Inuits. Homozygotes lack type I IFN immunity but are selectively vulnerable to influenza, COVID-19 pneumonia, and complications of live-attenuated viral vaccines.
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spelling pubmed-90700882022-10-29 Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic Meyts, Isabelle J Exp Med Insights In this issue of JEM, Bastard et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20220028) show that a loss-of-function IFNAR1 allele is common in western Polynesians, while Duncan et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212427) report that a loss-of-function IFNAR2 allele is common in Inuits. Homozygotes lack type I IFN immunity but are selectively vulnerable to influenza, COVID-19 pneumonia, and complications of live-attenuated viral vaccines. Rockefeller University Press 2022-04-29 /pmc/articles/PMC9070088/ /pubmed/35486090 http://dx.doi.org/10.1084/jem.20220491 Text en © 2022 Meyts https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Meyts, Isabelle
Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic
title Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic
title_full Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic
title_fullStr Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic
title_full_unstemmed Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic
title_short Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic
title_sort null ifnar1 and ifnar2 alleles are surprisingly common in the pacific and arctic
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070088/
https://www.ncbi.nlm.nih.gov/pubmed/35486090
http://dx.doi.org/10.1084/jem.20220491
work_keys_str_mv AT meytsisabelle nullifnar1andifnar2allelesaresurprisinglycommoninthepacificandarctic

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