Inhibition of miR-16 enhances the sensitivity of fibroblast-like synovial cells to methotrexate by restraining MDR1/P-gp expression via NF-κB pathway

MicroRNAs (miRNAs) are demonstrated to contribute to the regulation of drug resistance in a number of diseases. Nevertheless, little is known about the role and the underlying mechanism of miR-16 in rheumatoid arthritis (RA) methotrexate resistance. In this study, we firstly examined the miR-16 expr...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jing, Mao, Ni, Liu, Yiming, Xie, Xi, Tian, Jing, Li, Fen, Chen, Jinwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070447/
https://www.ncbi.nlm.nih.gov/pubmed/35528582
http://dx.doi.org/10.1039/c9ra04991f

Ejemplares similares

Ejemplares similares