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Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070482/ https://www.ncbi.nlm.nih.gov/pubmed/35531376 http://dx.doi.org/10.1093/ofid/ofac179 |
| _version_ | 1784700649610412032 |
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| author | Relph, Katharine A Russell, Clark D Fairfield, Cameron J Turtle, Lance de Silva, Thushan I Siggins, Matthew K Drake, Thomas M Thwaites, Ryan S Abrams, Simon Moore, Shona C Hardwick, Hayley E Oosthuyzen, Wilna Harrison, Ewen M Docherty, Annemarie B Openshaw, Peter J M Baillie, J Kenneth Semple, Malcolm G Ho, Antonia |
| author_facet | Relph, Katharine A Russell, Clark D Fairfield, Cameron J Turtle, Lance de Silva, Thushan I Siggins, Matthew K Drake, Thomas M Thwaites, Ryan S Abrams, Simon Moore, Shona C Hardwick, Hayley E Oosthuyzen, Wilna Harrison, Ewen M Docherty, Annemarie B Openshaw, Peter J M Baillie, J Kenneth Semple, Malcolm G Ho, Antonia |
| author_sort | Relph, Katharine A |
| collection | PubMed |
| description | Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11–1.70] ng/mL vs 0.24 [0.10–0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51–.60]). |
| format | Online Article Text |
| id | pubmed-9070482 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-90704822022-05-06 Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission Relph, Katharine A Russell, Clark D Fairfield, Cameron J Turtle, Lance de Silva, Thushan I Siggins, Matthew K Drake, Thomas M Thwaites, Ryan S Abrams, Simon Moore, Shona C Hardwick, Hayley E Oosthuyzen, Wilna Harrison, Ewen M Docherty, Annemarie B Openshaw, Peter J M Baillie, J Kenneth Semple, Malcolm G Ho, Antonia Open Forum Infect Dis Brief Report Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11–1.70] ng/mL vs 0.24 [0.10–0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51–.60]). Oxford University Press 2022-05-01 /pmc/articles/PMC9070482/ /pubmed/35531376 http://dx.doi.org/10.1093/ofid/ofac179 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Brief Report Relph, Katharine A Russell, Clark D Fairfield, Cameron J Turtle, Lance de Silva, Thushan I Siggins, Matthew K Drake, Thomas M Thwaites, Ryan S Abrams, Simon Moore, Shona C Hardwick, Hayley E Oosthuyzen, Wilna Harrison, Ewen M Docherty, Annemarie B Openshaw, Peter J M Baillie, J Kenneth Semple, Malcolm G Ho, Antonia Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission |
| title | Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission |
| title_full | Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission |
| title_fullStr | Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission |
| title_full_unstemmed | Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission |
| title_short | Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission |
| title_sort | procalcitonin is not a reliable biomarker of bacterial coinfection in people with coronavirus disease 2019 undergoing microbiological investigation at the time of hospital admission |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070482/ https://www.ncbi.nlm.nih.gov/pubmed/35531376 http://dx.doi.org/10.1093/ofid/ofac179 |
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