Detection of nucleic acids and other low abundance components in native bone and osteosarcoma extracellular matrix by isotope enrichment and DNP-enhanced NMR

Sensitivity enhancement by isotope enrichment and DNP NMR enables detection of minor but biologically relevant species in native intact bone, including nucleic acids, choline from phospholipid headgroups, and histidinyl and hydroxylysyl groups. Labelled matrix from the aggressive osteosarcoma K7M2 c...

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Detalles Bibliográficos
Autores principales: Goldberga, Ieva, Li, Rui, Chow, Wing Ying, Reid, David G., Bashtanova, Ulyana, Rajan, Rakesh, Puszkarska, Anna, Oschkinat, Hartmut, Duer, Melinda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070537/
https://www.ncbi.nlm.nih.gov/pubmed/35528564
http://dx.doi.org/10.1039/c9ra03198g

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