Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi

A solvent extract of the soft coral Sarcophyton ehrenbergi afforded cembrene diterpenoids, sarcoehrenbergilid D–F (1–3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional...

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Autores principales: Hegazy, Mohamed-Elamir F., Mohamed, Tarik A., Elshamy, Abdelsamed I., Hamed, Ahmed R., Ibrahim, Mahmoud A. A., Ohta, Shinji, Umeyama, Akemi, Paré, Paul W., Efferth, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070672/
https://www.ncbi.nlm.nih.gov/pubmed/35529183
http://dx.doi.org/10.1039/c9ra04158c
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author Hegazy, Mohamed-Elamir F.
Mohamed, Tarik A.
Elshamy, Abdelsamed I.
Hamed, Ahmed R.
Ibrahim, Mahmoud A. A.
Ohta, Shinji
Umeyama, Akemi
Paré, Paul W.
Efferth, Thomas
author_facet Hegazy, Mohamed-Elamir F.
Mohamed, Tarik A.
Elshamy, Abdelsamed I.
Hamed, Ahmed R.
Ibrahim, Mahmoud A. A.
Ohta, Shinji
Umeyama, Akemi
Paré, Paul W.
Efferth, Thomas
author_sort Hegazy, Mohamed-Elamir F.
collection PubMed
description A solvent extract of the soft coral Sarcophyton ehrenbergi afforded cembrene diterpenoids, sarcoehrenbergilid D–F (1–3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1–3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).
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spelling pubmed-90706722022-05-05 Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi Hegazy, Mohamed-Elamir F. Mohamed, Tarik A. Elshamy, Abdelsamed I. Hamed, Ahmed R. Ibrahim, Mahmoud A. A. Ohta, Shinji Umeyama, Akemi Paré, Paul W. Efferth, Thomas RSC Adv Chemistry A solvent extract of the soft coral Sarcophyton ehrenbergi afforded cembrene diterpenoids, sarcoehrenbergilid D–F (1–3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1–3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2). The Royal Society of Chemistry 2019-08-29 /pmc/articles/PMC9070672/ /pubmed/35529183 http://dx.doi.org/10.1039/c9ra04158c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Hegazy, Mohamed-Elamir F.
Mohamed, Tarik A.
Elshamy, Abdelsamed I.
Hamed, Ahmed R.
Ibrahim, Mahmoud A. A.
Ohta, Shinji
Umeyama, Akemi
Paré, Paul W.
Efferth, Thomas
Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi
title Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi
title_full Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi
title_fullStr Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi
title_full_unstemmed Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi
title_short Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi
title_sort sarcoehrenbergilides d–f: cytotoxic cembrene diterpenoids from the soft coral sarcophyton ehrenbergi
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070672/
https://www.ncbi.nlm.nih.gov/pubmed/35529183
http://dx.doi.org/10.1039/c9ra04158c
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