Assessment of sustained efficacy and resistance emergence under human-simulated exposure of cefiderocol against Acinetobacter baumannii using in vitro chemostat and in vivo murine infection models

OBJECTIVES: This study evaluated the sustained kill and potential for resistance development of Acinetobacter baumannii exposed to human-simulated exposure of cefiderocol over 72 h in in vitro and in vivo infection models. METHODS: Seven A. baumannii isolates with cefiderocol MICs of 0.12–2 mg/L wer...

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Detalles Bibliográficos
Autores principales: Gill, Christian M., Abdelraouf, Kamilia, Oota, Merime, Nakamura, Rio, Kuroiwa, Miho, Ishioka, Yoshino, Takemura, Miki, Yamano, Yoshinori, Nicolau, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070809/
https://www.ncbi.nlm.nih.gov/pubmed/35529054
http://dx.doi.org/10.1093/jacamr/dlac047

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