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Evaluation of blood cell count parameters as predictors of treatment failure of malaria in Angola: An observational study
BACKGROUND: Despite the guidelines provided by the World Health Organization for the treatment of malaria, treatment failure occurs in many hospitalized patients. OBJECTIVE: Evaluate whether blood cell count parameters may serve as predictors for malaria treatment. METHODOLOGY: A cross-sectional stu...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070872/ https://www.ncbi.nlm.nih.gov/pubmed/35511769 http://dx.doi.org/10.1371/journal.pone.0267671 |
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author | Sacomboio, Euclides Nenga Manuel dos Santos Sebastião, Cruz Salvador, Silvana Teresa da Costa João, Joaquim António Bapolo, Daisy Viviana Sebastião Francisco, Ngiambudulu M. Morais, Joana Valentim, Eduardo Ekundi |
author_facet | Sacomboio, Euclides Nenga Manuel dos Santos Sebastião, Cruz Salvador, Silvana Teresa da Costa João, Joaquim António Bapolo, Daisy Viviana Sebastião Francisco, Ngiambudulu M. Morais, Joana Valentim, Eduardo Ekundi |
author_sort | Sacomboio, Euclides Nenga Manuel |
collection | PubMed |
description | BACKGROUND: Despite the guidelines provided by the World Health Organization for the treatment of malaria, treatment failure occurs in many hospitalized patients. OBJECTIVE: Evaluate whether blood cell count parameters may serve as predictors for malaria treatment. METHODOLOGY: A cross-sectional study with a quantitative approach. RESULTS: Of the 219 patients, 21.5% showed failure to antimalarial treatment, Patient with 21 and 40 years (72.6%), male (53.4%), from peri-urban area (47.5%), with high parasitemia (59.8%), treated with Arthemeter (90.9%) and the mortality were 5.9%. Significant associations were observed between occupation, level of parasitemia and outcome with resistance to antimalarial treatment (p<0.05). Patients with normal Hb [OR: 0.75 (95% CI: 0.39–1.44), p = 0.393], RBC [OR: 0.83 (95% CI: 0.40–1.72), p = 0.632], RDW [OR: 0.54 (95% CI: 0.27–1.09), p = 0.088], MCV [OR: 0.61 (95% CI: 0.28–1.31), p = 0.204] were less likely to have malaria treatment failures after artemisinin-based therapy failure. In contrast, those with normal values of segmented neutrophils [OR: 0.32 (95% CI: 0.11–0.96), p = 0.042] and lymphocyte counts [OR: 0.24 (95% CI: 0.05–1.04), p = 0.055]. We also found that patients with significant low levels of Hct [OR: 0.31 (95% CI: 0.15–0.64) p = 0.002], and high leukocytes [OR: 8.88 (95% CI: 2.02–37.2), p = 0.004] and normal platelet values [OR: 1.42 (95% CI: 0.73–2.95), p = 0.280] demonstrated high probability of treatment failure. CONCLUSION: The importance of blood cell count parameters in monitoring malaria therapy necessitates the urgent need to re-evaluate Artemether-based therapy. Future studies involving more participants in different settings are needed to provide further evidence. |
format | Online Article Text |
id | pubmed-9070872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-90708722022-05-06 Evaluation of blood cell count parameters as predictors of treatment failure of malaria in Angola: An observational study Sacomboio, Euclides Nenga Manuel dos Santos Sebastião, Cruz Salvador, Silvana Teresa da Costa João, Joaquim António Bapolo, Daisy Viviana Sebastião Francisco, Ngiambudulu M. Morais, Joana Valentim, Eduardo Ekundi PLoS One Research Article BACKGROUND: Despite the guidelines provided by the World Health Organization for the treatment of malaria, treatment failure occurs in many hospitalized patients. OBJECTIVE: Evaluate whether blood cell count parameters may serve as predictors for malaria treatment. METHODOLOGY: A cross-sectional study with a quantitative approach. RESULTS: Of the 219 patients, 21.5% showed failure to antimalarial treatment, Patient with 21 and 40 years (72.6%), male (53.4%), from peri-urban area (47.5%), with high parasitemia (59.8%), treated with Arthemeter (90.9%) and the mortality were 5.9%. Significant associations were observed between occupation, level of parasitemia and outcome with resistance to antimalarial treatment (p<0.05). Patients with normal Hb [OR: 0.75 (95% CI: 0.39–1.44), p = 0.393], RBC [OR: 0.83 (95% CI: 0.40–1.72), p = 0.632], RDW [OR: 0.54 (95% CI: 0.27–1.09), p = 0.088], MCV [OR: 0.61 (95% CI: 0.28–1.31), p = 0.204] were less likely to have malaria treatment failures after artemisinin-based therapy failure. In contrast, those with normal values of segmented neutrophils [OR: 0.32 (95% CI: 0.11–0.96), p = 0.042] and lymphocyte counts [OR: 0.24 (95% CI: 0.05–1.04), p = 0.055]. We also found that patients with significant low levels of Hct [OR: 0.31 (95% CI: 0.15–0.64) p = 0.002], and high leukocytes [OR: 8.88 (95% CI: 2.02–37.2), p = 0.004] and normal platelet values [OR: 1.42 (95% CI: 0.73–2.95), p = 0.280] demonstrated high probability of treatment failure. CONCLUSION: The importance of blood cell count parameters in monitoring malaria therapy necessitates the urgent need to re-evaluate Artemether-based therapy. Future studies involving more participants in different settings are needed to provide further evidence. Public Library of Science 2022-05-05 /pmc/articles/PMC9070872/ /pubmed/35511769 http://dx.doi.org/10.1371/journal.pone.0267671 Text en © 2022 Sacomboio et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sacomboio, Euclides Nenga Manuel dos Santos Sebastião, Cruz Salvador, Silvana Teresa da Costa João, Joaquim António Bapolo, Daisy Viviana Sebastião Francisco, Ngiambudulu M. Morais, Joana Valentim, Eduardo Ekundi Evaluation of blood cell count parameters as predictors of treatment failure of malaria in Angola: An observational study |
title | Evaluation of blood cell count parameters as predictors of treatment failure of malaria in Angola: An observational study |
title_full | Evaluation of blood cell count parameters as predictors of treatment failure of malaria in Angola: An observational study |
title_fullStr | Evaluation of blood cell count parameters as predictors of treatment failure of malaria in Angola: An observational study |
title_full_unstemmed | Evaluation of blood cell count parameters as predictors of treatment failure of malaria in Angola: An observational study |
title_short | Evaluation of blood cell count parameters as predictors of treatment failure of malaria in Angola: An observational study |
title_sort | evaluation of blood cell count parameters as predictors of treatment failure of malaria in angola: an observational study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070872/ https://www.ncbi.nlm.nih.gov/pubmed/35511769 http://dx.doi.org/10.1371/journal.pone.0267671 |
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