Cargando…

Blood mRNA biomarkers distinguish variable systemic and sputum inflammation at treatment initiation of inhaled antibiotics in cystic fibrosis: A prospective non-randomized trial

Inhaled antibiotics control chronic airway infection and maintain respiratory health in cystic fibrosis (CF). Given variation in patient responses to inhaled antibiotics, the ability to identify distinct responder phenotypes would facilitate the delivery of personalized care. Previously, a 10-gene p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Caceres, Silvia M., Sanders, Linda A., Rysavy, Noel M., Poch, Katie R., Jones, Caroline R., Pickard, Kyle, Fingerlin, Tasha E., Marcus, Roland A., Malcolm, Kenneth C., Taylor-Cousar, Jennifer L., Nichols, David P., Nick, Jerry A., Strand, Matthew, Saavedra, Milene T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070878/ https://www.ncbi.nlm.nih.gov/pubmed/35511761 http://dx.doi.org/10.1371/journal.pone.0267592

Ejemplares similares

Specificity of Immunoglobulin Response to Nontuberculous Mycobacteria Infection in People with Cystic Fibrosis
por: Malcolm, Kenneth C., et al.
Publicado: (2022)

Deficient Complement Opsonization Impairs Mycobacterium avium Killing by Neutrophils in Cystic Fibrosis
por: Lenhart-Pendergrass, Patricia M., et al.
Publicado: (2023)

Corticosteroid use and increased CXCR2 levels on leukocytes are associated with lumacaftor/ivacaftor discontinuation in cystic fibrosis patients homozygous for the F508del CFTR mutation
por: Pohl, Kerstin, et al.
Publicado: (2018)

Systems serology in cystic fibrosis: Anti-Pseudomonas IgG1 responses and reduced lung function
por: Lu, Shiping, et al.
Publicado: (2023)

Extremes of Interferon-Stimulated Gene Expression Associate with Worse Outcomes in the Acute Respiratory Distress Syndrome
por: Nick, Jerry A., et al.
Publicado: (2016)

Divergent host innate immune response to the smooth-to-rough M. abscessus adaptation to chronic infection
por: Wheeler, Emily A, et al.
Publicado: (2023)

Neutrophil Extracellular Trap (NET)-Mediated Killing of Pseudomonas aeruginosa: Evidence of Acquired Resistance within the CF Airway, Independent of CFTR
por: Young, Robert L., et al.
Publicado: (2011)

Association of inhaled and systemic corticosteroid use with Coronavirus Disease 2019 (COVID-19) test positivity in patients with chronic pulmonary diseases
por: Liao, Shu-Yi, et al.
Publicado: (2021)

Potential of anti-inflammatory treatment for cystic fibrosis lung disease
por: Taylor-Cousar, Jennifer L, et al.
Publicado: (2010)

Neutrophil count in sputum is associated with increased sputum glucose and sputum L-lactate in cystic fibrosis
por: Nielsen, Bibi Uhre, et al.
Publicado: (2020)

Mycobacterium abscessus Induces a Limited Pattern of Neutrophil Activation That Promotes Pathogen Survival
por: Malcolm, Kenneth C., et al.
Publicado: (2013)

Azithromycin and the microbiota of cystic fibrosis sputum
por: Acosta, Nicole, et al.
Publicado: (2021)

The sputum transcriptome better predicts COPD exacerbations after the withdrawal of inhaled corticosteroids than sputum eosinophils
por: Ditz, Benedikt, et al.
Publicado: (2021)

Investigating Nontuberculous Mycobacteria Transmission at the Colorado Adult Cystic Fibrosis Program
por: Gross, Jane E., et al.
Publicado: (2022)

Prospective multicenter randomized patient recruitment and sample collection to enable future measurements of sputum biomarkers of inflammation in an observational study of cystic fibrosis
por: Liou, Theodore G., et al.
Publicado: (2019)

Sputum Bacterial Metacommunities in Distinguishing Heterogeneity in Respiratory Health and Disease
por: Si, Jiyeon, et al.
Publicado: (2022)

Glucose >200 mg/dL during Continuous Glucose Monitoring Identifies Adult Patients at Risk for Development of Cystic Fibrosis Related Diabetes
por: Taylor-Cousar, J. L., et al.
Publicado: (2016)

The combination of tezacaftor and ivacaftor in the treatment of patients with cystic fibrosis: clinical evidence and future prospects in cystic fibrosis therapy
por: Lommatzsch, Sherstin T., et al.
Publicado: (2019)

Developing Inhaled Antibiotics in Cystic Fibrosis: Current Challenges and Opportunities
por: Nichols, Dave P., et al.
Publicado: (2019)

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules
por: Schneider-Futschik, Elena K., et al.
Publicado: (2018)

Healthcare-associated links in transmission of nontuberculous mycobacteria among people with cystic fibrosis (HALT NTM) study: Rationale and study design
por: Gross, Jane E., et al.
Publicado: (2021)

Microbial, host and xenobiotic diversity in the cystic fibrosis sputum metabolome
por: Quinn, Robert A, et al.
Publicado: (2016)

Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis
por: Horsley, Alex, et al.
Publicado: (2014)

CFTR Modulators: Impact on Fertility, Pregnancy, and Lactation in Women with Cystic Fibrosis
por: Taylor-Cousar, Jennifer L.
Publicado: (2020)

Kinetics of TH2 biomarkers in sputum of asthmatics following inhaled allergen
por: Zuiker, Rob G. J. A., et al.
Publicado: (2015)

Microbiological profiles of sputum and gastric juice aspirates in Cystic Fibrosis patients
por: Al-momani, H., et al.
Publicado: (2016)

Management of pregnancy in cystic fibrosis
por: Montemayor, Kristina, et al.
Publicado: (2022)

Macrorheology of cystic fibrosis, chronic obstructive pulmonary disease & normal sputum
por: Serisier, David J, et al.
Publicado: (2009)

Compare the Effect of Inhaled Corticosteroids and Systemic Corticosteroids on Sputum Microbiome of AECOPD
por: Ma, Nan, et al.
Publicado: (2021)

Cystic Fibrosis Sputum Impairs the Ability of Neutrophils to Kill Staphylococcus aureus
por: Fantone, Kayla, et al.
Publicado: (2021)

The Inhibition of Superoxide Production by the Soluble Phase of Cystic Fibrosis Sputum
por: Dosanjh, Amrita
Publicado: (2008)

Sputum Biomarkers and the Prediction of Clinical Outcomes in Patients with Cystic Fibrosis
por: Liou, Theodore G., et al.
Publicado: (2012)

Isolation and characterization of microparticles in sputum from cystic fibrosis patients
por: Porro, Chiara, et al.
Publicado: (2010)

Sputum Metabolites Associated with Nontuberculous Mycobacterial Infection in Cystic Fibrosis
por: Breen, Paul, et al.
Publicado: (2022)

Impact of CFTR modulator use on outcomes in people with severe cystic fibrosis lung disease
por: Shteinberg, Michal, et al.
Publicado: (2020)

Molecular Epidemiologic Investigation of Mycobacterium intracellulare Subspecies chimaera Lung Infections at an Adult Cystic Fibrosis Program
por: Gross, Jane E., et al.
Publicado: (2023)

Evolution of the Gain-of-Function MUC5B Promoter Variant
por: Schwartz, David A., et al.
Publicado: (2022)

Olfactory dysfunction in people with cystic fibrosis with at least one copy of F508del
por: Beswick, Daniel M., et al.
Publicado: (2022)

Impact of Cystic Fibrosis Transmembrane Conductance Regulator Therapy on Chronic Rhinosinusitis and Health Status: Deep Learning CT Analysis and Patient-reported Outcomes
por: Beswick, Daniel M., et al.
Publicado: (2022)

eQTL mapping of rare variant associations using RNA-seq data: An evaluation of approaches
por: Lutz, Sharon Marie, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tdm01usi0mnhvirpbkkpmenjuq