Peptidoglycan pathways: there are still more!

The discovery of 3(rd) and 4(th) generations of currently existing classes of antibiotics has not hindered bacterial resistance, which is escalating at an alarming global level. This review follows WHO recommendations through implementing new criteria for newly discovered antibiotics. These recommen...

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Detalles Bibliográficos
Autores principales: Helal, Ahmed M., Sayed, Ahmed M., Omara, Mariam, Elsebaei, Mohamed M., Mayhoub, Abdelrahman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071014/
https://www.ncbi.nlm.nih.gov/pubmed/35530449
http://dx.doi.org/10.1039/c9ra04518j
Descripción
Sumario:The discovery of 3(rd) and 4(th) generations of currently existing classes of antibiotics has not hindered bacterial resistance, which is escalating at an alarming global level. This review follows WHO recommendations through implementing new criteria for newly discovered antibiotics. These recommendations focus on abandoning old scaffolds and hitting new targets. In light of these recommendations, this review discusses seven bacterial proteins that no commercial antibiotics have targeted yet, alongside their reported chemical scaffolds.

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