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Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis

Successful wound healing depends on the reconstruction of proper tissue homeostasis, particularly in the posttraumatic inflammatory tissue microenvironment. Diabetes jeopardizes tissues’ immune homeostasis in cutaneous wounds, causing persistent chronic inflammation and cytokine dysfunction. Previou...

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Autores principales: Yang, Yixi, Wang, Le, Zhou, Yonglin, He, Yijun, Lin, Shaozhang, Zeng, Yuwei, Zhou, Yunhe, Li, Wei, He, Zaopeng, Zhao, Qi, Chen, Lihao, Li, Zijie, Wang, Wenhao, Zhang, Zhi-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071060/
https://www.ncbi.nlm.nih.gov/pubmed/35529048
http://dx.doi.org/10.1093/rb/rbac023
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author Yang, Yixi
Wang, Le
Zhou, Yonglin
He, Yijun
Lin, Shaozhang
Zeng, Yuwei
Zhou, Yunhe
Li, Wei
He, Zaopeng
Zhao, Qi
Chen, Lihao
Li, Zijie
Wang, Wenhao
Zhang, Zhi-Yong
author_facet Yang, Yixi
Wang, Le
Zhou, Yonglin
He, Yijun
Lin, Shaozhang
Zeng, Yuwei
Zhou, Yunhe
Li, Wei
He, Zaopeng
Zhao, Qi
Chen, Lihao
Li, Zijie
Wang, Wenhao
Zhang, Zhi-Yong
author_sort Yang, Yixi
collection PubMed
description Successful wound healing depends on the reconstruction of proper tissue homeostasis, particularly in the posttraumatic inflammatory tissue microenvironment. Diabetes jeopardizes tissues’ immune homeostasis in cutaneous wounds, causing persistent chronic inflammation and cytokine dysfunction. Previously, we developed an autologous regeneration factor (ARF) technology to extract the cytokine composite from autologous tissue to restore immune homeostasis and promote wound healing. However, treatment efficacy was significantly compromised in diabetic conditions. Therefore, we proposed that a combination of melatonin and ARF, which is beneficial for proper immune homeostasis reconstruction, could be an effective treatment for diabetic wounds. Our research showed that the utilization of melatonin-mediated ARF biogel (AM gel) promoted diabetic wound regeneration at a more rapid healing rate. RNA-Seq analysis showed that AM gel treatment could restore more favorable immune tissue homeostasis with unique inflammatory patterning as a result of the diminished intensity of acute and chronic inflammation. Currently, AM gel could be a novel and promising therapeutic strategy for diabetic wounds in clinical practice through favorable immune homeostatic reconstructions in the tissue microenvironment and proper posttraumatic inflammation patterning.
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spelling pubmed-90710602022-05-06 Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis Yang, Yixi Wang, Le Zhou, Yonglin He, Yijun Lin, Shaozhang Zeng, Yuwei Zhou, Yunhe Li, Wei He, Zaopeng Zhao, Qi Chen, Lihao Li, Zijie Wang, Wenhao Zhang, Zhi-Yong Regen Biomater Research Article Successful wound healing depends on the reconstruction of proper tissue homeostasis, particularly in the posttraumatic inflammatory tissue microenvironment. Diabetes jeopardizes tissues’ immune homeostasis in cutaneous wounds, causing persistent chronic inflammation and cytokine dysfunction. Previously, we developed an autologous regeneration factor (ARF) technology to extract the cytokine composite from autologous tissue to restore immune homeostasis and promote wound healing. However, treatment efficacy was significantly compromised in diabetic conditions. Therefore, we proposed that a combination of melatonin and ARF, which is beneficial for proper immune homeostasis reconstruction, could be an effective treatment for diabetic wounds. Our research showed that the utilization of melatonin-mediated ARF biogel (AM gel) promoted diabetic wound regeneration at a more rapid healing rate. RNA-Seq analysis showed that AM gel treatment could restore more favorable immune tissue homeostasis with unique inflammatory patterning as a result of the diminished intensity of acute and chronic inflammation. Currently, AM gel could be a novel and promising therapeutic strategy for diabetic wounds in clinical practice through favorable immune homeostatic reconstructions in the tissue microenvironment and proper posttraumatic inflammation patterning. Oxford University Press 2022-04-29 /pmc/articles/PMC9071060/ /pubmed/35529048 http://dx.doi.org/10.1093/rb/rbac023 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Yixi
Wang, Le
Zhou, Yonglin
He, Yijun
Lin, Shaozhang
Zeng, Yuwei
Zhou, Yunhe
Li, Wei
He, Zaopeng
Zhao, Qi
Chen, Lihao
Li, Zijie
Wang, Wenhao
Zhang, Zhi-Yong
Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis
title Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis
title_full Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis
title_fullStr Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis
title_full_unstemmed Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis
title_short Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis
title_sort antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071060/
https://www.ncbi.nlm.nih.gov/pubmed/35529048
http://dx.doi.org/10.1093/rb/rbac023
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