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Transcriptional control of human gametogenesis

The pathways of gametogenesis encompass elaborate cellular specialization accompanied by precise partitioning of the genome content in order to produce fully matured spermatozoa and oocytes. Transcription factors are an important class of molecules that function in gametogenesis to regulate intrinsi...

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Autores principales: Fang, Fang, Iaquinta, Phillip J, Xia, Ninuo, Liu, Lei, Diao, Lei, Reijo Pera, Renee A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071081/
https://www.ncbi.nlm.nih.gov/pubmed/35297982
http://dx.doi.org/10.1093/humupd/dmac002
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author Fang, Fang
Iaquinta, Phillip J
Xia, Ninuo
Liu, Lei
Diao, Lei
Reijo Pera, Renee A
author_facet Fang, Fang
Iaquinta, Phillip J
Xia, Ninuo
Liu, Lei
Diao, Lei
Reijo Pera, Renee A
author_sort Fang, Fang
collection PubMed
description The pathways of gametogenesis encompass elaborate cellular specialization accompanied by precise partitioning of the genome content in order to produce fully matured spermatozoa and oocytes. Transcription factors are an important class of molecules that function in gametogenesis to regulate intrinsic gene expression programs, play essential roles in specifying (or determining) germ cell fate and assist in guiding full maturation of germ cells and maintenance of their populations. Moreover, in order to reinforce or redirect cell fate in vitro, it is transcription factors that are most frequently induced, over-expressed or activated. Many reviews have focused on the molecular development and genetics of gametogenesis, in vivo and in vitro, in model organisms and in humans, including several recent comprehensive reviews: here, we focus specifically on the role of transcription factors. Recent advances in stem cell biology and multi-omic studies have enabled deeper investigation into the unique transcriptional mechanisms of human reproductive development. Moreover, as methods continually improve, in vitro differentiation of germ cells can provide the platform for robust gain- and loss-of-function genetic analyses. These analyses are delineating unique and shared human germ cell transcriptional network components that, together with somatic lineage specifiers and pluripotency transcription factors, function in transitions from pluripotent stem cells to gametes. This grand theme review offers additional insight into human infertility and reproductive disorders that are linked predominantly to defects in the transcription factor networks and thus may potentially contribute to the development of novel treatments for infertility.
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spelling pubmed-90710812022-05-06 Transcriptional control of human gametogenesis Fang, Fang Iaquinta, Phillip J Xia, Ninuo Liu, Lei Diao, Lei Reijo Pera, Renee A Hum Reprod Update Grand Theme Review The pathways of gametogenesis encompass elaborate cellular specialization accompanied by precise partitioning of the genome content in order to produce fully matured spermatozoa and oocytes. Transcription factors are an important class of molecules that function in gametogenesis to regulate intrinsic gene expression programs, play essential roles in specifying (or determining) germ cell fate and assist in guiding full maturation of germ cells and maintenance of their populations. Moreover, in order to reinforce or redirect cell fate in vitro, it is transcription factors that are most frequently induced, over-expressed or activated. Many reviews have focused on the molecular development and genetics of gametogenesis, in vivo and in vitro, in model organisms and in humans, including several recent comprehensive reviews: here, we focus specifically on the role of transcription factors. Recent advances in stem cell biology and multi-omic studies have enabled deeper investigation into the unique transcriptional mechanisms of human reproductive development. Moreover, as methods continually improve, in vitro differentiation of germ cells can provide the platform for robust gain- and loss-of-function genetic analyses. These analyses are delineating unique and shared human germ cell transcriptional network components that, together with somatic lineage specifiers and pluripotency transcription factors, function in transitions from pluripotent stem cells to gametes. This grand theme review offers additional insight into human infertility and reproductive disorders that are linked predominantly to defects in the transcription factor networks and thus may potentially contribute to the development of novel treatments for infertility. Oxford University Press 2022-03-17 /pmc/articles/PMC9071081/ /pubmed/35297982 http://dx.doi.org/10.1093/humupd/dmac002 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Grand Theme Review
Fang, Fang
Iaquinta, Phillip J
Xia, Ninuo
Liu, Lei
Diao, Lei
Reijo Pera, Renee A
Transcriptional control of human gametogenesis
title Transcriptional control of human gametogenesis
title_full Transcriptional control of human gametogenesis
title_fullStr Transcriptional control of human gametogenesis
title_full_unstemmed Transcriptional control of human gametogenesis
title_short Transcriptional control of human gametogenesis
title_sort transcriptional control of human gametogenesis
topic Grand Theme Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071081/
https://www.ncbi.nlm.nih.gov/pubmed/35297982
http://dx.doi.org/10.1093/humupd/dmac002
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