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Transcriptional control of human gametogenesis
The pathways of gametogenesis encompass elaborate cellular specialization accompanied by precise partitioning of the genome content in order to produce fully matured spermatozoa and oocytes. Transcription factors are an important class of molecules that function in gametogenesis to regulate intrinsi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071081/ https://www.ncbi.nlm.nih.gov/pubmed/35297982 http://dx.doi.org/10.1093/humupd/dmac002 |
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author | Fang, Fang Iaquinta, Phillip J Xia, Ninuo Liu, Lei Diao, Lei Reijo Pera, Renee A |
author_facet | Fang, Fang Iaquinta, Phillip J Xia, Ninuo Liu, Lei Diao, Lei Reijo Pera, Renee A |
author_sort | Fang, Fang |
collection | PubMed |
description | The pathways of gametogenesis encompass elaborate cellular specialization accompanied by precise partitioning of the genome content in order to produce fully matured spermatozoa and oocytes. Transcription factors are an important class of molecules that function in gametogenesis to regulate intrinsic gene expression programs, play essential roles in specifying (or determining) germ cell fate and assist in guiding full maturation of germ cells and maintenance of their populations. Moreover, in order to reinforce or redirect cell fate in vitro, it is transcription factors that are most frequently induced, over-expressed or activated. Many reviews have focused on the molecular development and genetics of gametogenesis, in vivo and in vitro, in model organisms and in humans, including several recent comprehensive reviews: here, we focus specifically on the role of transcription factors. Recent advances in stem cell biology and multi-omic studies have enabled deeper investigation into the unique transcriptional mechanisms of human reproductive development. Moreover, as methods continually improve, in vitro differentiation of germ cells can provide the platform for robust gain- and loss-of-function genetic analyses. These analyses are delineating unique and shared human germ cell transcriptional network components that, together with somatic lineage specifiers and pluripotency transcription factors, function in transitions from pluripotent stem cells to gametes. This grand theme review offers additional insight into human infertility and reproductive disorders that are linked predominantly to defects in the transcription factor networks and thus may potentially contribute to the development of novel treatments for infertility. |
format | Online Article Text |
id | pubmed-9071081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-90710812022-05-06 Transcriptional control of human gametogenesis Fang, Fang Iaquinta, Phillip J Xia, Ninuo Liu, Lei Diao, Lei Reijo Pera, Renee A Hum Reprod Update Grand Theme Review The pathways of gametogenesis encompass elaborate cellular specialization accompanied by precise partitioning of the genome content in order to produce fully matured spermatozoa and oocytes. Transcription factors are an important class of molecules that function in gametogenesis to regulate intrinsic gene expression programs, play essential roles in specifying (or determining) germ cell fate and assist in guiding full maturation of germ cells and maintenance of their populations. Moreover, in order to reinforce or redirect cell fate in vitro, it is transcription factors that are most frequently induced, over-expressed or activated. Many reviews have focused on the molecular development and genetics of gametogenesis, in vivo and in vitro, in model organisms and in humans, including several recent comprehensive reviews: here, we focus specifically on the role of transcription factors. Recent advances in stem cell biology and multi-omic studies have enabled deeper investigation into the unique transcriptional mechanisms of human reproductive development. Moreover, as methods continually improve, in vitro differentiation of germ cells can provide the platform for robust gain- and loss-of-function genetic analyses. These analyses are delineating unique and shared human germ cell transcriptional network components that, together with somatic lineage specifiers and pluripotency transcription factors, function in transitions from pluripotent stem cells to gametes. This grand theme review offers additional insight into human infertility and reproductive disorders that are linked predominantly to defects in the transcription factor networks and thus may potentially contribute to the development of novel treatments for infertility. Oxford University Press 2022-03-17 /pmc/articles/PMC9071081/ /pubmed/35297982 http://dx.doi.org/10.1093/humupd/dmac002 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Grand Theme Review Fang, Fang Iaquinta, Phillip J Xia, Ninuo Liu, Lei Diao, Lei Reijo Pera, Renee A Transcriptional control of human gametogenesis |
title | Transcriptional control of human gametogenesis |
title_full | Transcriptional control of human gametogenesis |
title_fullStr | Transcriptional control of human gametogenesis |
title_full_unstemmed | Transcriptional control of human gametogenesis |
title_short | Transcriptional control of human gametogenesis |
title_sort | transcriptional control of human gametogenesis |
topic | Grand Theme Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071081/ https://www.ncbi.nlm.nih.gov/pubmed/35297982 http://dx.doi.org/10.1093/humupd/dmac002 |
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