Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model

Elevation of soluble wild-type (WT) tau occurs in synaptic compartments in Alzheimer’s disease. We addressed whether tau elevation affects synaptic transmission at the calyx of Held in slices from mice brainstem. Whole-cell loading of WT human tau (h-tau) in presynaptic terminals at 10–20 µM caused...

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Detalles Bibliográficos
Autores principales: Hori, Tetsuya, Eguchi, Kohgaku, Wang, Han-Ying, Miyasaka, Tomohiro, Guillaud, Laurent, Taoufiq, Zacharie, Mahapatra, Satyajit, Yamada, Hiroshi, Takei, Kohji, Takahashi, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071263/
https://www.ncbi.nlm.nih.gov/pubmed/35471147
http://dx.doi.org/10.7554/eLife.73542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071263/
https://www.ncbi.nlm.nih.gov/pubmed/35471147
http://dx.doi.org/10.7554/eLife.73542

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