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Multivalent DNA and nucleosome acidic patch interactions specify VRK1 mitotic localization and activity

A key role of chromatin kinases is to phosphorylate histone tails during mitosis to spatiotemporally regulate cell division. Vaccinia-related kinase 1 (VRK1) is a serine–threonine kinase that phosphorylates histone H3 threonine 3 (H3T3) along with other chromatin-based targets. While structural stud...

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Detalles Bibliográficos
Autores principales:	Budziszewski, Gabrielle R, Zhao, Yani, Spangler, Cathy J, Kedziora, Katarzyna M, Williams, Michael R, Azzam, Dalal N, Skrajna, Aleksandra, Koyama, Yuka, Cesmat, Andrew P, Simmons, Holly C, Arteaga, Eyla C, Strauss, Joshua D, Kireev, Dmitri, McGinty, Robert K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071384/ https://www.ncbi.nlm.nih.gov/pubmed/35390161 http://dx.doi.org/10.1093/nar/gkac198

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