SETDB1 fuels the lung cancer phenotype by modulating epigenome, 3D genome organization and chromatin mechanical properties

Imbalance in the finely orchestrated system of chromatin-modifying enzymes is a hallmark of many pathologies such as cancers, since causing the affection of the epigenome and transcriptional reprogramming. Here, we demonstrate that a loss-of-function mutation (LOF) of the major histone lysine methyl...

Descripción completa

Detalles Bibliográficos
Autores principales: Zakharova, Vlada V, Magnitov, Mikhail D, Del Maestro, Laurence, Ulianov, Sergey V, Glentis, Alexandros, Uyanik, Burhan, Williart, Alice, Karpukhina, Anna, Demidov, Oleg, Joliot, Veronique, Vassetzky, Yegor S, Mège, René-Marc, Piel, Matthieu, Razin, Sergey V, Ait-Si-Ali, Slimane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071401/
https://www.ncbi.nlm.nih.gov/pubmed/35474385
http://dx.doi.org/10.1093/nar/gkac234

Ejemplares similares

Ejemplares similares