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Mismatch discrimination and sequence bias during end-joining by DNA ligases

DNA ligases, critical enzymes for in vivo genome maintenance and modern molecular biology, catalyze the joining of adjacent 3′-OH and 5′-phosphorylated ends in DNA. To determine whether DNA annealing equilibria or properties intrinsic to the DNA ligase enzyme impact end-joining ligation outcomes, we...

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Detalles Bibliográficos
Autores principales:	Bilotti, Katharina, Potapov, Vladimir, Pryor, John M, Duckworth, Alexander T, Keck, James L, Lohman, Gregory J S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071435/ https://www.ncbi.nlm.nih.gov/pubmed/35438779 http://dx.doi.org/10.1093/nar/gkac241

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