Dynamic and facilitated binding of topoisomerase accelerates topological relaxation

How type 2 Topoisomerase (TopoII) proteins relax and simplify the topology of DNA molecules is one of the most intriguing open questions in genome and DNA biophysics. Most of the existing models neglect the dynamics of TopoII which is expected of proteins searching their targets via facilitated diff...

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Detalles Bibliográficos
Autores principales: Michieletto, Davide, Fosado, Yair A G, Melas, Elias, Baiesi, Marco, Tubiana, Luca, Orlandini, Enzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071436/
https://www.ncbi.nlm.nih.gov/pubmed/35474478
http://dx.doi.org/10.1093/nar/gkac260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071436/
https://www.ncbi.nlm.nih.gov/pubmed/35474478
http://dx.doi.org/10.1093/nar/gkac260

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