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Fragment screening and structural analyses highlight the ATP-assisted ligand binding for inhibitor discovery against type 1 methionyl-tRNA synthetase

Methionyl-tRNA synthetase (MetRS) charges tRNA(Met) with l-methionine (L-Met) to decode the ATG codon for protein translation, making it indispensable for all cellular lives. Many gram-positive bacteria use a type 1 MetRS (MetRS1), which is considered a promising antimicrobial drug target due to its...

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Detalles Bibliográficos
Autores principales:	Yi, Jia, Cai, Zhengjun, Qiu, Haipeng, Lu, Feihu, Luo, Zhiteng, Chen, Bingyi, Gu, Qiong, Xu, Jun, Zhou, Huihao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071491/ https://www.ncbi.nlm.nih.gov/pubmed/35474479 http://dx.doi.org/10.1093/nar/gkac285

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