Cargando…

Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue

Visceral adipose tissue (VAT) is a strong prognostic factor for cardiovascular disease and a potential target for cardiovascular risk stratification. Because VAT is difficult to measure in clinical practice, we estimated prediction models with predictors routinely measured in general practice and VA...

Descripción completa

Detalles Bibliográficos
Autores principales: Boone, Sebastiaan C, van Smeden, Maarten, Rosendaal, Frits R, le Cessie, Saskia, Groenwold, Rolf H H, Jukema, J Wouter, van Dijk, Ko Willems, Lamb, Hildo J, Greenland, Philip, Neeland, Ian J, Allison, Matthew A, Criqui, Michael H, Budoff, Matthew J, Lind, Lars L, Kullberg, Joel, Ahlström, Håkan, Mook-Kanamori, Dennis O, de Mutsert, Renée
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071575/
https://www.ncbi.nlm.nih.gov/pubmed/35015809
http://dx.doi.org/10.1093/aje/kwab298
_version_ 1784700867402792960
author Boone, Sebastiaan C
van Smeden, Maarten
Rosendaal, Frits R
le Cessie, Saskia
Groenwold, Rolf H H
Jukema, J Wouter
van Dijk, Ko Willems
Lamb, Hildo J
Greenland, Philip
Neeland, Ian J
Allison, Matthew A
Criqui, Michael H
Budoff, Matthew J
Lind, Lars L
Kullberg, Joel
Ahlström, Håkan
Mook-Kanamori, Dennis O
de Mutsert, Renée
author_facet Boone, Sebastiaan C
van Smeden, Maarten
Rosendaal, Frits R
le Cessie, Saskia
Groenwold, Rolf H H
Jukema, J Wouter
van Dijk, Ko Willems
Lamb, Hildo J
Greenland, Philip
Neeland, Ian J
Allison, Matthew A
Criqui, Michael H
Budoff, Matthew J
Lind, Lars L
Kullberg, Joel
Ahlström, Håkan
Mook-Kanamori, Dennis O
de Mutsert, Renée
author_sort Boone, Sebastiaan C
collection PubMed
description Visceral adipose tissue (VAT) is a strong prognostic factor for cardiovascular disease and a potential target for cardiovascular risk stratification. Because VAT is difficult to measure in clinical practice, we estimated prediction models with predictors routinely measured in general practice and VAT as outcome using ridge regression in 2,501 middle-aged participants from the Netherlands Epidemiology of Obesity study, 2008–2012. Adding waist circumference and other anthropometric measurements on top of the routinely measured variables improved the optimism-adjusted R(2) from 0.50 to 0.58 with a decrease in the root-mean-square error (RMSE) from 45.6 to 41.5 cm(2) and with overall good calibration. Further addition of predominantly lipoprotein-related metabolites from the Nightingale platform did not improve the optimism-corrected R(2) and RMSE. The models were externally validated in 370 participants from the Prospective Investigation of Vasculature in Uppsala Seniors (PIVUS, 2006–2009) and 1,901 participants from the Multi-Ethnic Study of Atherosclerosis (MESA, 2000–2007). Performance was comparable to the development setting in PIVUS (R(2) = 0.63, RMSE = 42.4 cm(2), calibration slope = 0.94) but lower in MESA (R(2) = 0.44, RMSE = 60.7 cm(2), calibration slope = 0.75). Our findings indicate that the estimation of VAT with routine clinical measurements can be substantially improved by incorporating waist circumference but not by metabolite measurements.
format Online
Article
Text
id pubmed-9071575
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-90715752022-05-06 Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue Boone, Sebastiaan C van Smeden, Maarten Rosendaal, Frits R le Cessie, Saskia Groenwold, Rolf H H Jukema, J Wouter van Dijk, Ko Willems Lamb, Hildo J Greenland, Philip Neeland, Ian J Allison, Matthew A Criqui, Michael H Budoff, Matthew J Lind, Lars L Kullberg, Joel Ahlström, Håkan Mook-Kanamori, Dennis O de Mutsert, Renée Am J Epidemiol Original Contribution Visceral adipose tissue (VAT) is a strong prognostic factor for cardiovascular disease and a potential target for cardiovascular risk stratification. Because VAT is difficult to measure in clinical practice, we estimated prediction models with predictors routinely measured in general practice and VAT as outcome using ridge regression in 2,501 middle-aged participants from the Netherlands Epidemiology of Obesity study, 2008–2012. Adding waist circumference and other anthropometric measurements on top of the routinely measured variables improved the optimism-adjusted R(2) from 0.50 to 0.58 with a decrease in the root-mean-square error (RMSE) from 45.6 to 41.5 cm(2) and with overall good calibration. Further addition of predominantly lipoprotein-related metabolites from the Nightingale platform did not improve the optimism-corrected R(2) and RMSE. The models were externally validated in 370 participants from the Prospective Investigation of Vasculature in Uppsala Seniors (PIVUS, 2006–2009) and 1,901 participants from the Multi-Ethnic Study of Atherosclerosis (MESA, 2000–2007). Performance was comparable to the development setting in PIVUS (R(2) = 0.63, RMSE = 42.4 cm(2), calibration slope = 0.94) but lower in MESA (R(2) = 0.44, RMSE = 60.7 cm(2), calibration slope = 0.75). Our findings indicate that the estimation of VAT with routine clinical measurements can be substantially improved by incorporating waist circumference but not by metabolite measurements. Oxford University Press 2022-01-06 /pmc/articles/PMC9071575/ /pubmed/35015809 http://dx.doi.org/10.1093/aje/kwab298 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Contribution
Boone, Sebastiaan C
van Smeden, Maarten
Rosendaal, Frits R
le Cessie, Saskia
Groenwold, Rolf H H
Jukema, J Wouter
van Dijk, Ko Willems
Lamb, Hildo J
Greenland, Philip
Neeland, Ian J
Allison, Matthew A
Criqui, Michael H
Budoff, Matthew J
Lind, Lars L
Kullberg, Joel
Ahlström, Håkan
Mook-Kanamori, Dennis O
de Mutsert, Renée
Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue
title Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue
title_full Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue
title_fullStr Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue
title_full_unstemmed Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue
title_short Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue
title_sort evaluation of the value of waist circumference and metabolomics in the estimation of visceral adipose tissue
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071575/
https://www.ncbi.nlm.nih.gov/pubmed/35015809
http://dx.doi.org/10.1093/aje/kwab298
work_keys_str_mv AT boonesebastiaanc evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT vansmedenmaarten evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT rosendaalfritsr evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT lecessiesaskia evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT groenwoldrolfhh evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT jukemajwouter evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT vandijkkowillems evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT lambhildoj evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT greenlandphilip evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT neelandianj evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT allisonmatthewa evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT criquimichaelh evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT budoffmatthewj evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT lindlarsl evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT kullbergjoel evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT ahlstromhakan evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT mookkanamoridenniso evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue
AT demutsertrenee evaluationofthevalueofwaistcircumferenceandmetabolomicsintheestimationofvisceraladiposetissue