Enantiomeric helical TiO(2) nanofibers modulate different peptide assemblies and subsequent cellular behaviors

The effect of the morphological chirality of inorganic TiO(2) nanofibers on peptide assembly and cellular behaviors was investigated. Model peptide insulin maintains its native structure and served as a growth factor for promoting proliferation and differentiation of PC12 cells on the surface of rig...

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Detalles Bibliográficos
Autores principales: Jie, Xu, Xu, Deng, Wei, Weili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071841/
https://www.ncbi.nlm.nih.gov/pubmed/35528423
http://dx.doi.org/10.1039/c9ra04660g
Descripción
Sumario:The effect of the morphological chirality of inorganic TiO(2) nanofibers on peptide assembly and cellular behaviors was investigated. Model peptide insulin maintains its native structure and served as a growth factor for promoting proliferation and differentiation of PC12 cells on the surface of right-handed TiO(2). In contrast, insulin forms amyloid fibrils and loses its bioactivity on the left-handed TiO(2).

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