Enantiomeric helical TiO(2) nanofibers modulate different peptide assemblies and subsequent cellular behaviors

The effect of the morphological chirality of inorganic TiO(2) nanofibers on peptide assembly and cellular behaviors was investigated. Model peptide insulin maintains its native structure and served as a growth factor for promoting proliferation and differentiation of PC12 cells on the surface of rig...

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Detalles Bibliográficos
Autores principales: Jie, Xu, Xu, Deng, Wei, Weili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071841/
https://www.ncbi.nlm.nih.gov/pubmed/35528423
http://dx.doi.org/10.1039/c9ra04660g
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author Jie, Xu
Xu, Deng
Wei, Weili
author_facet Jie, Xu
Xu, Deng
Wei, Weili
author_sort Jie, Xu
collection PubMed
description The effect of the morphological chirality of inorganic TiO(2) nanofibers on peptide assembly and cellular behaviors was investigated. Model peptide insulin maintains its native structure and served as a growth factor for promoting proliferation and differentiation of PC12 cells on the surface of right-handed TiO(2). In contrast, insulin forms amyloid fibrils and loses its bioactivity on the left-handed TiO(2).
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spelling pubmed-90718412022-05-06 Enantiomeric helical TiO(2) nanofibers modulate different peptide assemblies and subsequent cellular behaviors Jie, Xu Xu, Deng Wei, Weili RSC Adv Chemistry The effect of the morphological chirality of inorganic TiO(2) nanofibers on peptide assembly and cellular behaviors was investigated. Model peptide insulin maintains its native structure and served as a growth factor for promoting proliferation and differentiation of PC12 cells on the surface of right-handed TiO(2). In contrast, insulin forms amyloid fibrils and loses its bioactivity on the left-handed TiO(2). The Royal Society of Chemistry 2019-09-17 /pmc/articles/PMC9071841/ /pubmed/35528423 http://dx.doi.org/10.1039/c9ra04660g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Jie, Xu
Xu, Deng
Wei, Weili
Enantiomeric helical TiO(2) nanofibers modulate different peptide assemblies and subsequent cellular behaviors
title Enantiomeric helical TiO(2) nanofibers modulate different peptide assemblies and subsequent cellular behaviors
title_full Enantiomeric helical TiO(2) nanofibers modulate different peptide assemblies and subsequent cellular behaviors
title_fullStr Enantiomeric helical TiO(2) nanofibers modulate different peptide assemblies and subsequent cellular behaviors
title_full_unstemmed Enantiomeric helical TiO(2) nanofibers modulate different peptide assemblies and subsequent cellular behaviors
title_short Enantiomeric helical TiO(2) nanofibers modulate different peptide assemblies and subsequent cellular behaviors
title_sort enantiomeric helical tio(2) nanofibers modulate different peptide assemblies and subsequent cellular behaviors
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071841/
https://www.ncbi.nlm.nih.gov/pubmed/35528423
http://dx.doi.org/10.1039/c9ra04660g
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AT xudeng enantiomerichelicaltio2nanofibersmodulatedifferentpeptideassembliesandsubsequentcellularbehaviors
AT weiweili enantiomerichelicaltio2nanofibersmodulatedifferentpeptideassembliesandsubsequentcellularbehaviors

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