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A ceRNA Network Composed of Survival-Related lncRNAs, miRNAs, and mRNAs in Clear Cell Renal Carcinoma

Clear cell renal carcinoma (ccRCC) is one of the most common renal carcinomas worldwide, which has worse prognosis compared with other subtypes of tumors. We propose a potential RNA regulatory mechanism associated with ccRCC progression. Accordingly, we screened out clinical factors and the expressi...

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Autores principales: Lu, Wenjun, Liu, Hengchen, Zhang, Xin, Guo, Yujun, Liu, Lu, Guo, Tieyun, Qu, Liqin, Yang, Shulong, Li, Zhaozhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071875/
https://www.ncbi.nlm.nih.gov/pubmed/35529267
http://dx.doi.org/10.1155/2022/8504441
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author Lu, Wenjun
Liu, Hengchen
Zhang, Xin
Guo, Yujun
Liu, Lu
Guo, Tieyun
Qu, Liqin
Yang, Shulong
Li, Zhaozhu
author_facet Lu, Wenjun
Liu, Hengchen
Zhang, Xin
Guo, Yujun
Liu, Lu
Guo, Tieyun
Qu, Liqin
Yang, Shulong
Li, Zhaozhu
author_sort Lu, Wenjun
collection PubMed
description Clear cell renal carcinoma (ccRCC) is one of the most common renal carcinomas worldwide, which has worse prognosis compared with other subtypes of tumors. We propose a potential RNA regulatory mechanism associated with ccRCC progression. Accordingly, we screened out clinical factors and the expression of RNAs and miRNAs of ccRCC from the TCGA database. 9 lncRNAs (FGF12-AS2, WT1-AS, TRIM36-IT1, AC009093.1, LINC00443, TCL6, COL18A1-AS1, AC110619.1, HOTTIP), 2 miRNAs (mir-155 and mir-21), and 3 mRNAs (COL4A4, ERMP1, PRELID2) were selected from differential expression RNAs and built predictive survival models. The survival models performed very well in predicting prognosis and were found to be highly correlated with tumor stage. In addition, the survival-related lncRNA-miRNA-mRNA (ceRNA) network was constructed by 18 RNAs including 12 mRNAs, 2 miRNAs, and 4 lncRNAs. It is found that the “ECM-receptor interaction,” “Pathways in cancer,” and “Chemokine signaling pathway” as the main pathways in KEGG pathway analysis. Overall, we established predictive survival model and ceRNA network based on multivariate Cox regression analysis. It may open a new approach and potential biomarkers for clinical prognosis and treatment of ccRCC patients.
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spelling pubmed-90718752022-05-06 A ceRNA Network Composed of Survival-Related lncRNAs, miRNAs, and mRNAs in Clear Cell Renal Carcinoma Lu, Wenjun Liu, Hengchen Zhang, Xin Guo, Yujun Liu, Lu Guo, Tieyun Qu, Liqin Yang, Shulong Li, Zhaozhu Comput Math Methods Med Research Article Clear cell renal carcinoma (ccRCC) is one of the most common renal carcinomas worldwide, which has worse prognosis compared with other subtypes of tumors. We propose a potential RNA regulatory mechanism associated with ccRCC progression. Accordingly, we screened out clinical factors and the expression of RNAs and miRNAs of ccRCC from the TCGA database. 9 lncRNAs (FGF12-AS2, WT1-AS, TRIM36-IT1, AC009093.1, LINC00443, TCL6, COL18A1-AS1, AC110619.1, HOTTIP), 2 miRNAs (mir-155 and mir-21), and 3 mRNAs (COL4A4, ERMP1, PRELID2) were selected from differential expression RNAs and built predictive survival models. The survival models performed very well in predicting prognosis and were found to be highly correlated with tumor stage. In addition, the survival-related lncRNA-miRNA-mRNA (ceRNA) network was constructed by 18 RNAs including 12 mRNAs, 2 miRNAs, and 4 lncRNAs. It is found that the “ECM-receptor interaction,” “Pathways in cancer,” and “Chemokine signaling pathway” as the main pathways in KEGG pathway analysis. Overall, we established predictive survival model and ceRNA network based on multivariate Cox regression analysis. It may open a new approach and potential biomarkers for clinical prognosis and treatment of ccRCC patients. Hindawi 2022-04-28 /pmc/articles/PMC9071875/ /pubmed/35529267 http://dx.doi.org/10.1155/2022/8504441 Text en Copyright © 2022 Wenjun Lu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lu, Wenjun
Liu, Hengchen
Zhang, Xin
Guo, Yujun
Liu, Lu
Guo, Tieyun
Qu, Liqin
Yang, Shulong
Li, Zhaozhu
A ceRNA Network Composed of Survival-Related lncRNAs, miRNAs, and mRNAs in Clear Cell Renal Carcinoma
title A ceRNA Network Composed of Survival-Related lncRNAs, miRNAs, and mRNAs in Clear Cell Renal Carcinoma
title_full A ceRNA Network Composed of Survival-Related lncRNAs, miRNAs, and mRNAs in Clear Cell Renal Carcinoma
title_fullStr A ceRNA Network Composed of Survival-Related lncRNAs, miRNAs, and mRNAs in Clear Cell Renal Carcinoma
title_full_unstemmed A ceRNA Network Composed of Survival-Related lncRNAs, miRNAs, and mRNAs in Clear Cell Renal Carcinoma
title_short A ceRNA Network Composed of Survival-Related lncRNAs, miRNAs, and mRNAs in Clear Cell Renal Carcinoma
title_sort cerna network composed of survival-related lncrnas, mirnas, and mrnas in clear cell renal carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071875/
https://www.ncbi.nlm.nih.gov/pubmed/35529267
http://dx.doi.org/10.1155/2022/8504441
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