Co-catalyzed ortho-C–H functionalization/annulation of arenes and alkenes with alkynylsilanes: access to isoquinolone and pyridone motifs

A method for cobalt-catalyzed ortho-C–H functionalization annulation of arenes and alkenes with alkynylsilanes assisted by 8-aminoquinolyl auxiliary has been described. Alkynylsilanes were employed as the coupling partners to react with a broad range of benzamides and acrylamides, affording the corr...

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Detalles Bibliográficos
Autores principales: Lin, Cong, Shen, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072155/
https://www.ncbi.nlm.nih.gov/pubmed/35529370
http://dx.doi.org/10.1039/c9ra06963a
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author Lin, Cong
Shen, Liang
author_facet Lin, Cong
Shen, Liang
author_sort Lin, Cong
collection PubMed
description A method for cobalt-catalyzed ortho-C–H functionalization annulation of arenes and alkenes with alkynylsilanes assisted by 8-aminoquinolyl auxiliary has been described. Alkynylsilanes were employed as the coupling partners to react with a broad range of benzamides and acrylamides, affording the corresponding isoquinolone and pyridone derivatives in moderate to high yields. It is worth noting that the silyl group in the final products can be retained or removed by switching the reaction conditions.
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spelling pubmed-90721552022-05-06 Co-catalyzed ortho-C–H functionalization/annulation of arenes and alkenes with alkynylsilanes: access to isoquinolone and pyridone motifs Lin, Cong Shen, Liang RSC Adv Chemistry A method for cobalt-catalyzed ortho-C–H functionalization annulation of arenes and alkenes with alkynylsilanes assisted by 8-aminoquinolyl auxiliary has been described. Alkynylsilanes were employed as the coupling partners to react with a broad range of benzamides and acrylamides, affording the corresponding isoquinolone and pyridone derivatives in moderate to high yields. It is worth noting that the silyl group in the final products can be retained or removed by switching the reaction conditions. The Royal Society of Chemistry 2019-09-26 /pmc/articles/PMC9072155/ /pubmed/35529370 http://dx.doi.org/10.1039/c9ra06963a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Lin, Cong
Shen, Liang
Co-catalyzed ortho-C–H functionalization/annulation of arenes and alkenes with alkynylsilanes: access to isoquinolone and pyridone motifs
title Co-catalyzed ortho-C–H functionalization/annulation of arenes and alkenes with alkynylsilanes: access to isoquinolone and pyridone motifs
title_full Co-catalyzed ortho-C–H functionalization/annulation of arenes and alkenes with alkynylsilanes: access to isoquinolone and pyridone motifs
title_fullStr Co-catalyzed ortho-C–H functionalization/annulation of arenes and alkenes with alkynylsilanes: access to isoquinolone and pyridone motifs
title_full_unstemmed Co-catalyzed ortho-C–H functionalization/annulation of arenes and alkenes with alkynylsilanes: access to isoquinolone and pyridone motifs
title_short Co-catalyzed ortho-C–H functionalization/annulation of arenes and alkenes with alkynylsilanes: access to isoquinolone and pyridone motifs
title_sort co-catalyzed ortho-c–h functionalization/annulation of arenes and alkenes with alkynylsilanes: access to isoquinolone and pyridone motifs
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072155/
https://www.ncbi.nlm.nih.gov/pubmed/35529370
http://dx.doi.org/10.1039/c9ra06963a
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AT shenliang cocatalyzedorthochfunctionalizationannulationofarenesandalkeneswithalkynylsilanesaccesstoisoquinoloneandpyridonemotifs

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