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An injectable molecular hydrogel assembled by antimicrobial peptide PAF26 for antimicrobial application

Wound infection is a crucial factor that inhibits wound recovery. A feasible measure to solve this problem is using antimicrobial biomaterials to suppress the microbial growth. In this work, an amphipathic antimicrobial peptide (Ac-RKKWFW-NH(2), PAF26) was investigated to form the antimicrobial hydr...

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Detalles Bibliográficos
Autores principales: Cao, Fengyi, Mei, Lin, Zhu, Genxing, Song, Meng, Zhang, Xueli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072196/
https://www.ncbi.nlm.nih.gov/pubmed/35529366
http://dx.doi.org/10.1039/c9ra06130d
Descripción
Sumario:Wound infection is a crucial factor that inhibits wound recovery. A feasible measure to solve this problem is using antimicrobial biomaterials to suppress the microbial growth. In this work, an amphipathic antimicrobial peptide (Ac-RKKWFW-NH(2), PAF26) was investigated to form the antimicrobial hydrogel. Triggered by pH, PAF26 peptide could self-assemble into a hydrogel, and the hydrogel formed was injectable and exhibited shear-thinning ability. Antimicrobial experiments demonstrated that the self-assembled hydrogel had an outstanding antimicrobial ability against pathogenic microbes such as Candida albicans, Staphylococcus aureus, and Escherichia coli via destroying the cell membrane structure. Thus, this study provides a novel method for preparing an injectable antimicrobial peptide hydrogel for antimicrobial therapies.