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Transition metal-free one-pot synthesis of substituted pyrroles by employing aza-Wittig reaction

A mild and metal-free one-pot synthetic strategy has been developed for the construction of substituted pyrroles by employing aza-Wittig reaction from a unique and unexplored combination of chromones and phenacyl azides. This method does not compromise the diverse substitutions on both the phenacyl...

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Detalles Bibliográficos
Autores principales: Jadala, Chetna, Prasad, Budaganaboyina, Prasanthi, A. V. G., Shankaraiah, Nagula, Kamal, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072206/
https://www.ncbi.nlm.nih.gov/pubmed/35529397
http://dx.doi.org/10.1039/c9ra06778g
Descripción
Sumario:A mild and metal-free one-pot synthetic strategy has been developed for the construction of substituted pyrroles by employing aza-Wittig reaction from a unique and unexplored combination of chromones and phenacyl azides. This method does not compromise the diverse substitutions on both the phenacyl azides and chromones. The merits of this method are wide substrate scope, easy functionalization, short reaction time, operationally simple, and higher yields. Moreover, this method is amenable for the generation of a library of key pyrrole building blocks.