A multicomponent, facile and catalyst-free microwave-assisted protocol for the synthesis of pyrazolo-[3,4-b]-quinolines under green conditions

A facile, swift and ecofriendly microwave-assisted multi-component/one-pot protocol is designed for the synthesis of novel pyrazolo-[3,4-b]-quinolines at ambient temperature in aqueous ethanol as a reaction medium. The 18 novel pyrazolo-[3,4-b]-quinoline derivatives were synthesized by fusion of cho...

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Detalles Bibliográficos
Autores principales: Robert Khumalo, Mandlenkosi, Maddila, Surya Narayana, Maddila, Suresh, Jonnalagadda, Sreekantha B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072209/
https://www.ncbi.nlm.nih.gov/pubmed/35529349
http://dx.doi.org/10.1039/c9ra04604f
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author Robert Khumalo, Mandlenkosi
Maddila, Surya Narayana
Maddila, Suresh
Jonnalagadda, Sreekantha B.
author_facet Robert Khumalo, Mandlenkosi
Maddila, Surya Narayana
Maddila, Suresh
Jonnalagadda, Sreekantha B.
author_sort Robert Khumalo, Mandlenkosi
collection PubMed
description A facile, swift and ecofriendly microwave-assisted multi-component/one-pot protocol is designed for the synthesis of novel pyrazolo-[3,4-b]-quinolines at ambient temperature in aqueous ethanol as a reaction medium. The 18 novel pyrazolo-[3,4-b]-quinoline derivatives were synthesized by fusion of chosen aryl aldehyde, dimedone and 5-amino-3-methyl-1-phenylpyrazole in excellent yields (91–98%). All the molecular structures were confirmed by (1)H-NMR, (15)N-NMR, (13)C-NMR, and HRMS data analysis. Operational simplicity, easy handling, one-step simple workup procedure, mild reaction conditions, short reaction time (≤10 min), high selectivity and no by-product formation are the striking features of the protocol.
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spelling pubmed-90722092022-05-06 A multicomponent, facile and catalyst-free microwave-assisted protocol for the synthesis of pyrazolo-[3,4-b]-quinolines under green conditions Robert Khumalo, Mandlenkosi Maddila, Surya Narayana Maddila, Suresh Jonnalagadda, Sreekantha B. RSC Adv Chemistry A facile, swift and ecofriendly microwave-assisted multi-component/one-pot protocol is designed for the synthesis of novel pyrazolo-[3,4-b]-quinolines at ambient temperature in aqueous ethanol as a reaction medium. The 18 novel pyrazolo-[3,4-b]-quinoline derivatives were synthesized by fusion of chosen aryl aldehyde, dimedone and 5-amino-3-methyl-1-phenylpyrazole in excellent yields (91–98%). All the molecular structures were confirmed by (1)H-NMR, (15)N-NMR, (13)C-NMR, and HRMS data analysis. Operational simplicity, easy handling, one-step simple workup procedure, mild reaction conditions, short reaction time (≤10 min), high selectivity and no by-product formation are the striking features of the protocol. The Royal Society of Chemistry 2019-09-30 /pmc/articles/PMC9072209/ /pubmed/35529349 http://dx.doi.org/10.1039/c9ra04604f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Robert Khumalo, Mandlenkosi
Maddila, Surya Narayana
Maddila, Suresh
Jonnalagadda, Sreekantha B.
A multicomponent, facile and catalyst-free microwave-assisted protocol for the synthesis of pyrazolo-[3,4-b]-quinolines under green conditions
title A multicomponent, facile and catalyst-free microwave-assisted protocol for the synthesis of pyrazolo-[3,4-b]-quinolines under green conditions
title_full A multicomponent, facile and catalyst-free microwave-assisted protocol for the synthesis of pyrazolo-[3,4-b]-quinolines under green conditions
title_fullStr A multicomponent, facile and catalyst-free microwave-assisted protocol for the synthesis of pyrazolo-[3,4-b]-quinolines under green conditions
title_full_unstemmed A multicomponent, facile and catalyst-free microwave-assisted protocol for the synthesis of pyrazolo-[3,4-b]-quinolines under green conditions
title_short A multicomponent, facile and catalyst-free microwave-assisted protocol for the synthesis of pyrazolo-[3,4-b]-quinolines under green conditions
title_sort multicomponent, facile and catalyst-free microwave-assisted protocol for the synthesis of pyrazolo-[3,4-b]-quinolines under green conditions
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072209/
https://www.ncbi.nlm.nih.gov/pubmed/35529349
http://dx.doi.org/10.1039/c9ra04604f
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