Oxone promoted dehydrogenative Povarov cyclization of N-aryl glycine derivatives: an approach towards quinoline fused lactones and lactams

Oxone promoted intramolecular dehydrogenative imino Diels–Alder reaction (Povarov cyclization) of alkyne tethered N-aryl glycine esters and amides has been explored, thus affording biologically significant quinoline fused lactones and lactams. The reaction is simple, scalable, and high yielding (up...

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Detalles Bibliográficos
Autores principales: More, Devidas A., Shinde, Ganesh H., Shaikh, Aslam C., Muthukrishnan, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072217/
https://www.ncbi.nlm.nih.gov/pubmed/35530246
http://dx.doi.org/10.1039/c9ra06212b
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author More, Devidas A.
Shinde, Ganesh H.
Shaikh, Aslam C.
Muthukrishnan, M.
author_facet More, Devidas A.
Shinde, Ganesh H.
Shaikh, Aslam C.
Muthukrishnan, M.
author_sort More, Devidas A.
collection PubMed
description Oxone promoted intramolecular dehydrogenative imino Diels–Alder reaction (Povarov cyclization) of alkyne tethered N-aryl glycine esters and amides has been explored, thus affording biologically significant quinoline fused lactones and lactams. The reaction is simple, scalable, and high yielding (up to 88%). The method was further extended to prepare biologically important luotonin-A analogues and the quinoline core of uncialamycin.
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spelling pubmed-90722172022-05-06 Oxone promoted dehydrogenative Povarov cyclization of N-aryl glycine derivatives: an approach towards quinoline fused lactones and lactams More, Devidas A. Shinde, Ganesh H. Shaikh, Aslam C. Muthukrishnan, M. RSC Adv Chemistry Oxone promoted intramolecular dehydrogenative imino Diels–Alder reaction (Povarov cyclization) of alkyne tethered N-aryl glycine esters and amides has been explored, thus affording biologically significant quinoline fused lactones and lactams. The reaction is simple, scalable, and high yielding (up to 88%). The method was further extended to prepare biologically important luotonin-A analogues and the quinoline core of uncialamycin. The Royal Society of Chemistry 2019-09-25 /pmc/articles/PMC9072217/ /pubmed/35530246 http://dx.doi.org/10.1039/c9ra06212b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
More, Devidas A.
Shinde, Ganesh H.
Shaikh, Aslam C.
Muthukrishnan, M.
Oxone promoted dehydrogenative Povarov cyclization of N-aryl glycine derivatives: an approach towards quinoline fused lactones and lactams
title Oxone promoted dehydrogenative Povarov cyclization of N-aryl glycine derivatives: an approach towards quinoline fused lactones and lactams
title_full Oxone promoted dehydrogenative Povarov cyclization of N-aryl glycine derivatives: an approach towards quinoline fused lactones and lactams
title_fullStr Oxone promoted dehydrogenative Povarov cyclization of N-aryl glycine derivatives: an approach towards quinoline fused lactones and lactams
title_full_unstemmed Oxone promoted dehydrogenative Povarov cyclization of N-aryl glycine derivatives: an approach towards quinoline fused lactones and lactams
title_short Oxone promoted dehydrogenative Povarov cyclization of N-aryl glycine derivatives: an approach towards quinoline fused lactones and lactams
title_sort oxone promoted dehydrogenative povarov cyclization of n-aryl glycine derivatives: an approach towards quinoline fused lactones and lactams
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072217/
https://www.ncbi.nlm.nih.gov/pubmed/35530246
http://dx.doi.org/10.1039/c9ra06212b
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