Copper-catalyzed chemoselective synthesis of 4-trifluoromethyl pyrazoles

A series of 4-trifluoromethyl pyrazoles have been prepared via the copper-catalyzed cycloaddition of 2-bromo-3,3,3-trifluoropropene with a variety of N-arylsydnone derivatives under mild conditions. This new protocol under optimized reaction conditions [Cu(OTf)(2)/phen, DBU, CH(3)CN, 35 °C] afforded...

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Detalles Bibliográficos
Autores principales: Lu, Jiaqing, Man, Yuning, Zhang, Yabin, Lin, Bo, Lin, Qi, Weng, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072218/
https://www.ncbi.nlm.nih.gov/pubmed/35529353
http://dx.doi.org/10.1039/c9ra07694h
Descripción
Sumario:A series of 4-trifluoromethyl pyrazoles have been prepared via the copper-catalyzed cycloaddition of 2-bromo-3,3,3-trifluoropropene with a variety of N-arylsydnone derivatives under mild conditions. This new protocol under optimized reaction conditions [Cu(OTf)(2)/phen, DBU, CH(3)CN, 35 °C] afforded 4-trifluoromethyl pyrazoles in moderate to excellent yields with excellent regioselectivity.

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