Copper-catalyzed chemoselective synthesis of 4-trifluoromethyl pyrazoles

A series of 4-trifluoromethyl pyrazoles have been prepared via the copper-catalyzed cycloaddition of 2-bromo-3,3,3-trifluoropropene with a variety of N-arylsydnone derivatives under mild conditions. This new protocol under optimized reaction conditions [Cu(OTf)(2)/phen, DBU, CH(3)CN, 35 °C] afforded...

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Autores principales: Lu, Jiaqing, Man, Yuning, Zhang, Yabin, Lin, Bo, Lin, Qi, Weng, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072218/
https://www.ncbi.nlm.nih.gov/pubmed/35529353
http://dx.doi.org/10.1039/c9ra07694h
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author Lu, Jiaqing
Man, Yuning
Zhang, Yabin
Lin, Bo
Lin, Qi
Weng, Zhiqiang
author_facet Lu, Jiaqing
Man, Yuning
Zhang, Yabin
Lin, Bo
Lin, Qi
Weng, Zhiqiang
author_sort Lu, Jiaqing
collection PubMed
description A series of 4-trifluoromethyl pyrazoles have been prepared via the copper-catalyzed cycloaddition of 2-bromo-3,3,3-trifluoropropene with a variety of N-arylsydnone derivatives under mild conditions. This new protocol under optimized reaction conditions [Cu(OTf)(2)/phen, DBU, CH(3)CN, 35 °C] afforded 4-trifluoromethyl pyrazoles in moderate to excellent yields with excellent regioselectivity.
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spelling pubmed-90722182022-05-06 Copper-catalyzed chemoselective synthesis of 4-trifluoromethyl pyrazoles Lu, Jiaqing Man, Yuning Zhang, Yabin Lin, Bo Lin, Qi Weng, Zhiqiang RSC Adv Chemistry A series of 4-trifluoromethyl pyrazoles have been prepared via the copper-catalyzed cycloaddition of 2-bromo-3,3,3-trifluoropropene with a variety of N-arylsydnone derivatives under mild conditions. This new protocol under optimized reaction conditions [Cu(OTf)(2)/phen, DBU, CH(3)CN, 35 °C] afforded 4-trifluoromethyl pyrazoles in moderate to excellent yields with excellent regioselectivity. The Royal Society of Chemistry 2019-09-30 /pmc/articles/PMC9072218/ /pubmed/35529353 http://dx.doi.org/10.1039/c9ra07694h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Lu, Jiaqing
Man, Yuning
Zhang, Yabin
Lin, Bo
Lin, Qi
Weng, Zhiqiang
Copper-catalyzed chemoselective synthesis of 4-trifluoromethyl pyrazoles
title Copper-catalyzed chemoselective synthesis of 4-trifluoromethyl pyrazoles
title_full Copper-catalyzed chemoselective synthesis of 4-trifluoromethyl pyrazoles
title_fullStr Copper-catalyzed chemoselective synthesis of 4-trifluoromethyl pyrazoles
title_full_unstemmed Copper-catalyzed chemoselective synthesis of 4-trifluoromethyl pyrazoles
title_short Copper-catalyzed chemoselective synthesis of 4-trifluoromethyl pyrazoles
title_sort copper-catalyzed chemoselective synthesis of 4-trifluoromethyl pyrazoles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072218/
https://www.ncbi.nlm.nih.gov/pubmed/35529353
http://dx.doi.org/10.1039/c9ra07694h
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