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Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR

DNA damage response (DDR) is a highly conserved genome surveillance mechanism that preserves cell viability in the presence of chemotherapeutic drugs. Hence, small molecules that inhibit DDR are expected to enhance the anti-cancer effect of chemotherapy. Through a recent chemical library screen, we...

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Detalles Bibliográficos
Autores principales:	Wang, Fangfang, Jin, Sora, Mayca Pozo, Franklin, Tian, Danmei, Tang, Xiyang, Dai, Yi, Yao, Xinsheng, Tang, Jinshan, Zhang, Youwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072232/ https://www.ncbi.nlm.nih.gov/pubmed/35530159 http://dx.doi.org/10.1016/j.apsb.2021.08.025

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