c-MYC-mediated TRIB3/P62(+) aggresomes accumulation triggers paraptosis upon the combination of everolimus and ginsenoside Rh2

The mammalian target of rapamycin (mTOR) pathway is abnormally activated in lung cancer. However, the anti-lung cancer effect of mTOR inhibitors as monotherapy is modest. Here, we identified that ginsenoside Rh2, an active component of Panax ginseng C. A. Mey., enhanced the anti-cancer effect of the...

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Detalles Bibliográficos
Autores principales: Su, Min-Xia, Xu, Yu-Lian, Jiang, Xiao-Ming, Huang, Mu-Yang, Zhang, Le-Le, Yuan, Luo-Wei, Xu, Xiao-Huang, Zhu, Qi, Gao, Jian-Li, Lu, Jia-Hong, Chen, Xiuping, Huang, Ming-Qing, Wang, Yitao, Lu, Jin-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072243/
https://www.ncbi.nlm.nih.gov/pubmed/35530150
http://dx.doi.org/10.1016/j.apsb.2021.09.014

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