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In vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study
Systematic administration of painkillers and anti-inflammatory drugs is routinely employed to minimize pain and bodily disorders. Controlled drug delivery has the potential to improve the outcomes of disorders by providing sustained exposure to efficacious drug concentrations. Herein, we report the...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072301/ https://www.ncbi.nlm.nih.gov/pubmed/35529386 http://dx.doi.org/10.1039/c9ra05025f |
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author | Gull, Nafisa Khan, Shahzad Maqsood Zahid Butt, Muhammad Taqi Khalid, Syed Shafiq, Muhammad Islam, Atif Asim, Sumreen Hafeez, Sadaf Khan, Rafi Ullah |
author_facet | Gull, Nafisa Khan, Shahzad Maqsood Zahid Butt, Muhammad Taqi Khalid, Syed Shafiq, Muhammad Islam, Atif Asim, Sumreen Hafeez, Sadaf Khan, Rafi Ullah |
author_sort | Gull, Nafisa |
collection | PubMed |
description | Systematic administration of painkillers and anti-inflammatory drugs is routinely employed to minimize pain and bodily disorders. Controlled drug delivery has the potential to improve the outcomes of disorders by providing sustained exposure to efficacious drug concentrations. Herein, we report the fabrication of multi-responsive hydrogels using reactive and functional polymers such as chitosan and polyvinyl pyrrolidone by varying the concentration of a cleavable crosslinker, tetraethyl orthosilicate. The swelling indices of the hydrogels were evaluated in distilled water, solutions with different pH values and different electrolytes. FTIR, WAXRD and TGA were conducted to investigate the structures, crystallinities and thermal stabilities of the prepared multi-responsive hydrogels, respectively. The ultimate tensile strength and elongations at break of the fabricated hydrogels were investigated to assess their mechanical stability. Optical microscopy, biodegradation, antimicrobial and cytotoxicity analyses were further carried out to verify the magnified crosslinked and porous structures, biodegradabilities, biocompatibilities and toxic behaviour of the as-prepared hydrogels, respectively. Drug release analysis was conducted to evaluate their release behaviour in PBS, SGF, SIF and electrolyte solutions. The overall results indicate the successful development of novel, non-toxic and sustained drug deliverable hydrogels, which can be considered as a paramount success towards the fabrication of controlled drug delivery systems. |
format | Online Article Text |
id | pubmed-9072301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90723012022-05-06 In vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study Gull, Nafisa Khan, Shahzad Maqsood Zahid Butt, Muhammad Taqi Khalid, Syed Shafiq, Muhammad Islam, Atif Asim, Sumreen Hafeez, Sadaf Khan, Rafi Ullah RSC Adv Chemistry Systematic administration of painkillers and anti-inflammatory drugs is routinely employed to minimize pain and bodily disorders. Controlled drug delivery has the potential to improve the outcomes of disorders by providing sustained exposure to efficacious drug concentrations. Herein, we report the fabrication of multi-responsive hydrogels using reactive and functional polymers such as chitosan and polyvinyl pyrrolidone by varying the concentration of a cleavable crosslinker, tetraethyl orthosilicate. The swelling indices of the hydrogels were evaluated in distilled water, solutions with different pH values and different electrolytes. FTIR, WAXRD and TGA were conducted to investigate the structures, crystallinities and thermal stabilities of the prepared multi-responsive hydrogels, respectively. The ultimate tensile strength and elongations at break of the fabricated hydrogels were investigated to assess their mechanical stability. Optical microscopy, biodegradation, antimicrobial and cytotoxicity analyses were further carried out to verify the magnified crosslinked and porous structures, biodegradabilities, biocompatibilities and toxic behaviour of the as-prepared hydrogels, respectively. Drug release analysis was conducted to evaluate their release behaviour in PBS, SGF, SIF and electrolyte solutions. The overall results indicate the successful development of novel, non-toxic and sustained drug deliverable hydrogels, which can be considered as a paramount success towards the fabrication of controlled drug delivery systems. The Royal Society of Chemistry 2019-10-01 /pmc/articles/PMC9072301/ /pubmed/35529386 http://dx.doi.org/10.1039/c9ra05025f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Gull, Nafisa Khan, Shahzad Maqsood Zahid Butt, Muhammad Taqi Khalid, Syed Shafiq, Muhammad Islam, Atif Asim, Sumreen Hafeez, Sadaf Khan, Rafi Ullah In vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study |
title |
In vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study |
title_full |
In vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study |
title_fullStr |
In vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study |
title_full_unstemmed |
In vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study |
title_short |
In vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study |
title_sort | in vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072301/ https://www.ncbi.nlm.nih.gov/pubmed/35529386 http://dx.doi.org/10.1039/c9ra05025f |
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