Concise synthesis of N-thiomethyl benzoimidazoles through base-promoted sequential multicomponent assembly

An efficient method for the synthesis of N-thiomethyl benzimidazoles from o-phenylenediamines, thiophenols, and aldehydes via C–N/C–S bond formation under metal-free conditions is described. A broad range of functional groups attached to the substrates were well tolerated in this reaction system. St...

Descripción completa

Detalles Bibliográficos
Autores principales: Tian, Jingxin, Yuan, Shanshan, Xiao, Fuhong, Huang, Huawen, Deng, Guo-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072308/
https://www.ncbi.nlm.nih.gov/pubmed/35530231
http://dx.doi.org/10.1039/c9ra06144d
_version_ 1784701031753449472
author Tian, Jingxin
Yuan, Shanshan
Xiao, Fuhong
Huang, Huawen
Deng, Guo-Jun
author_facet Tian, Jingxin
Yuan, Shanshan
Xiao, Fuhong
Huang, Huawen
Deng, Guo-Jun
author_sort Tian, Jingxin
collection PubMed
description An efficient method for the synthesis of N-thiomethyl benzimidazoles from o-phenylenediamines, thiophenols, and aldehydes via C–N/C–S bond formation under metal-free conditions is described. A broad range of functional groups attached to the substrates were well tolerated in this reaction system. Stable and low-toxicity paraformaldehyde was used as the carbon source.
format Online
Article
Text
id pubmed-9072308
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-90723082022-05-06 Concise synthesis of N-thiomethyl benzoimidazoles through base-promoted sequential multicomponent assembly Tian, Jingxin Yuan, Shanshan Xiao, Fuhong Huang, Huawen Deng, Guo-Jun RSC Adv Chemistry An efficient method for the synthesis of N-thiomethyl benzimidazoles from o-phenylenediamines, thiophenols, and aldehydes via C–N/C–S bond formation under metal-free conditions is described. A broad range of functional groups attached to the substrates were well tolerated in this reaction system. Stable and low-toxicity paraformaldehyde was used as the carbon source. The Royal Society of Chemistry 2019-09-26 /pmc/articles/PMC9072308/ /pubmed/35530231 http://dx.doi.org/10.1039/c9ra06144d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Tian, Jingxin
Yuan, Shanshan
Xiao, Fuhong
Huang, Huawen
Deng, Guo-Jun
Concise synthesis of N-thiomethyl benzoimidazoles through base-promoted sequential multicomponent assembly
title Concise synthesis of N-thiomethyl benzoimidazoles through base-promoted sequential multicomponent assembly
title_full Concise synthesis of N-thiomethyl benzoimidazoles through base-promoted sequential multicomponent assembly
title_fullStr Concise synthesis of N-thiomethyl benzoimidazoles through base-promoted sequential multicomponent assembly
title_full_unstemmed Concise synthesis of N-thiomethyl benzoimidazoles through base-promoted sequential multicomponent assembly
title_short Concise synthesis of N-thiomethyl benzoimidazoles through base-promoted sequential multicomponent assembly
title_sort concise synthesis of n-thiomethyl benzoimidazoles through base-promoted sequential multicomponent assembly
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072308/
https://www.ncbi.nlm.nih.gov/pubmed/35530231
http://dx.doi.org/10.1039/c9ra06144d
work_keys_str_mv AT tianjingxin concisesynthesisofnthiomethylbenzoimidazolesthroughbasepromotedsequentialmulticomponentassembly
AT yuanshanshan concisesynthesisofnthiomethylbenzoimidazolesthroughbasepromotedsequentialmulticomponentassembly
AT xiaofuhong concisesynthesisofnthiomethylbenzoimidazolesthroughbasepromotedsequentialmulticomponentassembly
AT huanghuawen concisesynthesisofnthiomethylbenzoimidazolesthroughbasepromotedsequentialmulticomponentassembly
AT dengguojun concisesynthesisofnthiomethylbenzoimidazolesthroughbasepromotedsequentialmulticomponentassembly

Ejemplares similares