Cargando…

Upper airway flow characteristics of childhood obstructive sleep apnea-hypopnea syndrome

Revealing the structural morphology and inner flow field of the upper airway is important for understanding obstructive sleep apnea-hypopnea syndrome (OSAHS) incidence phenomena and pathological diagnosis in children. However, prior work on this topic has been focused on adults and the findings cann...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Huikun, Xu, Chang, Xue, Haoyang, Guo, Yufeng, Su, Lijun, Gao, Xingqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072398/
https://www.ncbi.nlm.nih.gov/pubmed/35513462
http://dx.doi.org/10.1038/s41598-022-10367-w
_version_ 1784701052453388288
author Cai, Huikun
Xu, Chang
Xue, Haoyang
Guo, Yufeng
Su, Lijun
Gao, Xingqiang
author_facet Cai, Huikun
Xu, Chang
Xue, Haoyang
Guo, Yufeng
Su, Lijun
Gao, Xingqiang
author_sort Cai, Huikun
collection PubMed
description Revealing the structural morphology and inner flow field of the upper airway is important for understanding obstructive sleep apnea-hypopnea syndrome (OSAHS) incidence phenomena and pathological diagnosis in children. However, prior work on this topic has been focused on adults and the findings cannot be directly extrapolated to children because of different inducing factors. Therefore, this paper employs a simulation method to investigate upper airway flow characteristics of childhood OSAHS. It is found that the Reynold number changes highly throughout the whole upper airway, and the laminar assumption is no longer suitable for low Reynold number flow, which is much unlike classic fluid mechanics. Turbulent models of Standard k-ω and Spalart-Allmaras were developed prior to suggestion. The simulation is validated by experiments with an error of approximately 20%. Additionally, carried out in this analysis is the influence of adenoidal hypertrophy with different narrow levels. The cross-sectional area, flow velocity, pressure drop and volume rate will change greatly when the narrow level is above 64% of the upper airway, which can be a quantitative explanation for medical intervention if adenoid hypertrophy blocks 2/3 of the upper airway in the common clinical judgment of otorhinolaryngology. It is expected that this paper can be a meaningful instruction on OSAHS surgery plan making as well as recovery evaluation postoperatively.
format Online
Article
Text
id pubmed-9072398
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-90723982022-05-07 Upper airway flow characteristics of childhood obstructive sleep apnea-hypopnea syndrome Cai, Huikun Xu, Chang Xue, Haoyang Guo, Yufeng Su, Lijun Gao, Xingqiang Sci Rep Article Revealing the structural morphology and inner flow field of the upper airway is important for understanding obstructive sleep apnea-hypopnea syndrome (OSAHS) incidence phenomena and pathological diagnosis in children. However, prior work on this topic has been focused on adults and the findings cannot be directly extrapolated to children because of different inducing factors. Therefore, this paper employs a simulation method to investigate upper airway flow characteristics of childhood OSAHS. It is found that the Reynold number changes highly throughout the whole upper airway, and the laminar assumption is no longer suitable for low Reynold number flow, which is much unlike classic fluid mechanics. Turbulent models of Standard k-ω and Spalart-Allmaras were developed prior to suggestion. The simulation is validated by experiments with an error of approximately 20%. Additionally, carried out in this analysis is the influence of adenoidal hypertrophy with different narrow levels. The cross-sectional area, flow velocity, pressure drop and volume rate will change greatly when the narrow level is above 64% of the upper airway, which can be a quantitative explanation for medical intervention if adenoid hypertrophy blocks 2/3 of the upper airway in the common clinical judgment of otorhinolaryngology. It is expected that this paper can be a meaningful instruction on OSAHS surgery plan making as well as recovery evaluation postoperatively. Nature Publishing Group UK 2022-05-05 /pmc/articles/PMC9072398/ /pubmed/35513462 http://dx.doi.org/10.1038/s41598-022-10367-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Cai, Huikun
Xu, Chang
Xue, Haoyang
Guo, Yufeng
Su, Lijun
Gao, Xingqiang
Upper airway flow characteristics of childhood obstructive sleep apnea-hypopnea syndrome
title Upper airway flow characteristics of childhood obstructive sleep apnea-hypopnea syndrome
title_full Upper airway flow characteristics of childhood obstructive sleep apnea-hypopnea syndrome
title_fullStr Upper airway flow characteristics of childhood obstructive sleep apnea-hypopnea syndrome
title_full_unstemmed Upper airway flow characteristics of childhood obstructive sleep apnea-hypopnea syndrome
title_short Upper airway flow characteristics of childhood obstructive sleep apnea-hypopnea syndrome
title_sort upper airway flow characteristics of childhood obstructive sleep apnea-hypopnea syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072398/
https://www.ncbi.nlm.nih.gov/pubmed/35513462
http://dx.doi.org/10.1038/s41598-022-10367-w
work_keys_str_mv AT caihuikun upperairwayflowcharacteristicsofchildhoodobstructivesleepapneahypopneasyndrome
AT xuchang upperairwayflowcharacteristicsofchildhoodobstructivesleepapneahypopneasyndrome
AT xuehaoyang upperairwayflowcharacteristicsofchildhoodobstructivesleepapneahypopneasyndrome
AT guoyufeng upperairwayflowcharacteristicsofchildhoodobstructivesleepapneahypopneasyndrome
AT sulijun upperairwayflowcharacteristicsofchildhoodobstructivesleepapneahypopneasyndrome
AT gaoxingqiang upperairwayflowcharacteristicsofchildhoodobstructivesleepapneahypopneasyndrome