Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS

The SLC25 carrier family consists of 53 transporters that shuttle nutrients and co-factors across mitochondrial membranes. The family is highly redundant and their transport activities coupled to metabolic state. Here, we use a pooled, dual CRISPR screening strategy that knocks out pairs of transpor...

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Detalles Bibliográficos
Autores principales: Shi, Xiaojian, Reinstadler, Bryn, Shah, Hardik, To, Tsz-Leung, Byrne, Katie, Summer, Luanna, Calvo, Sarah E., Goldberger, Olga, Doench, John G., Mootha, Vamsi K., Shen, Hongying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072411/
https://www.ncbi.nlm.nih.gov/pubmed/35513392
http://dx.doi.org/10.1038/s41467-022-30126-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072411/
https://www.ncbi.nlm.nih.gov/pubmed/35513392
http://dx.doi.org/10.1038/s41467-022-30126-9

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