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Comparative optimization of combinatorial CRISPR screens

Combinatorial CRISPR technologies have emerged as a transformative approach to systematically probe genetic interactions and dependencies of redundant gene pairs. However, the performance of different functional genomic tools for multiplexing sgRNAs vary widely. Here, we generate and benchmark ten d...

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Detalles Bibliográficos
Autores principales:	Li, Ruitong, Klingbeil, Olaf, Monducci, Davide, Young, Michael J., Rodriguez, Diego J., Bayyat, Zaid, Dempster, Joshua M., Kesar, Devishi, Yang, Xiaoping, Zamanighomi, Mahdi, Vakoc, Christopher R., Ito, Takahiro, Sellers, William R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072436/ https://www.ncbi.nlm.nih.gov/pubmed/35513429 http://dx.doi.org/10.1038/s41467-022-30196-9

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