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Unwanted hydrolysis or α/β-peptide bond formation: how long should the rate-limiting coupling step take?
Nowadays, in Solid Phase Peptide Synthesis (SPPS), being either manual, automated, continuous flow or microwave-assisted, the reaction with various coupling reagents takes place via in situ active ester formation. In this study, the formation and stability of these key active esters were investigate...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072530/ https://www.ncbi.nlm.nih.gov/pubmed/35529379 http://dx.doi.org/10.1039/c9ra06124j |