FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes

Fibroblast growth factor (FGF) 21, a hormone that increases insulin sensitivity, has shown promise as a therapeutic agent to improve metabolic dysregulation. Here we report that FGF21 directly targets cardiac myocytes by binding β-klotho and FGF receptor (FGFR) 4. In combination with high glucose, F...

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Detalles Bibliográficos
Autores principales: Yanucil, Christopher, Kentrup, Dominik, Li, Xueyi, Grabner, Alexander, Schramm, Karla, Martinez, Eliana C., Li, Jinliang, Campos, Isaac, Czaya, Brian, Heitman, Kylie, Westbrook, David, Wende, Adam R., Sloan, Alexis, Roche, Johanna M., Fornoni, Alessia, Kapiloff, Michael S., Faul, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072546/
https://www.ncbi.nlm.nih.gov/pubmed/35513431
http://dx.doi.org/10.1038/s41598-022-11033-x

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