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Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure

Cells are exposed to oxidative stress and reactive metabolites every day. The Nrf2 signaling pathway responds to oxidative stress by upregulation of antioxidants like glutathione (GSH) to compensate the stress insult and re-establish homeostasis. Although mechanisms describing the interaction betwee...

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Detalles Bibliográficos
Autores principales:	Hiemstra, Steven, Fehling-Kaschek, Mirjam, Kuijper, Isoude A., Bischoff, Luc J. M., Wijaya, Lukas S., Rosenblatt, Marcus, Esselink, Jeroen, van Egmond, Allard, Mos, Jornt, Beltman, Joost B., Timmer, Jens, van de Water, Bob, Kaschek, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072554/ https://www.ncbi.nlm.nih.gov/pubmed/35513409 http://dx.doi.org/10.1038/s41598-022-10857-x

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