Iodine-catalyzed sulfonylation of sulfonyl hydrazides with tert-amines: a green and efficient protocol for the synthesis of sulfonamides

This study provides a direct, sustainable and eco-friendly method for the synthesis of various sulfonamides via the sulfonylation of sulfonyl hydrazides with tert-amines. The method utilizes sulfonyl hydrazides to oxidize and couple with tertiary amines through selective cleavage of C–N bonds. In th...

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Detalles Bibliográficos
Autores principales: Chen, Jinyang, Han, Xiaoran, Mei, Lan, Liu, Jinchuan, Du, Kui, Cao, Tuanwu, Li, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072569/
https://www.ncbi.nlm.nih.gov/pubmed/35527951
http://dx.doi.org/10.1039/c9ra07361b
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author Chen, Jinyang
Han, Xiaoran
Mei, Lan
Liu, Jinchuan
Du, Kui
Cao, Tuanwu
Li, Qiang
author_facet Chen, Jinyang
Han, Xiaoran
Mei, Lan
Liu, Jinchuan
Du, Kui
Cao, Tuanwu
Li, Qiang
author_sort Chen, Jinyang
collection PubMed
description This study provides a direct, sustainable and eco-friendly method for the synthesis of various sulfonamides via the sulfonylation of sulfonyl hydrazides with tert-amines. The method utilizes sulfonyl hydrazides to oxidize and couple with tertiary amines through selective cleavage of C–N bonds. In this reaction, molecular iodine was used as the catalyst and t-butyl hydroperoxide was used as the oxidant.
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spelling pubmed-90725692022-05-06 Iodine-catalyzed sulfonylation of sulfonyl hydrazides with tert-amines: a green and efficient protocol for the synthesis of sulfonamides Chen, Jinyang Han, Xiaoran Mei, Lan Liu, Jinchuan Du, Kui Cao, Tuanwu Li, Qiang RSC Adv Chemistry This study provides a direct, sustainable and eco-friendly method for the synthesis of various sulfonamides via the sulfonylation of sulfonyl hydrazides with tert-amines. The method utilizes sulfonyl hydrazides to oxidize and couple with tertiary amines through selective cleavage of C–N bonds. In this reaction, molecular iodine was used as the catalyst and t-butyl hydroperoxide was used as the oxidant. The Royal Society of Chemistry 2019-10-02 /pmc/articles/PMC9072569/ /pubmed/35527951 http://dx.doi.org/10.1039/c9ra07361b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Chen, Jinyang
Han, Xiaoran
Mei, Lan
Liu, Jinchuan
Du, Kui
Cao, Tuanwu
Li, Qiang
Iodine-catalyzed sulfonylation of sulfonyl hydrazides with tert-amines: a green and efficient protocol for the synthesis of sulfonamides
title Iodine-catalyzed sulfonylation of sulfonyl hydrazides with tert-amines: a green and efficient protocol for the synthesis of sulfonamides
title_full Iodine-catalyzed sulfonylation of sulfonyl hydrazides with tert-amines: a green and efficient protocol for the synthesis of sulfonamides
title_fullStr Iodine-catalyzed sulfonylation of sulfonyl hydrazides with tert-amines: a green and efficient protocol for the synthesis of sulfonamides
title_full_unstemmed Iodine-catalyzed sulfonylation of sulfonyl hydrazides with tert-amines: a green and efficient protocol for the synthesis of sulfonamides
title_short Iodine-catalyzed sulfonylation of sulfonyl hydrazides with tert-amines: a green and efficient protocol for the synthesis of sulfonamides
title_sort iodine-catalyzed sulfonylation of sulfonyl hydrazides with tert-amines: a green and efficient protocol for the synthesis of sulfonamides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072569/
https://www.ncbi.nlm.nih.gov/pubmed/35527951
http://dx.doi.org/10.1039/c9ra07361b
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