Mending a broken heart with novel cardiogenic small molecules

Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury. Du et al., reporting in Cell Stem Cell, employ a FUCCI- and MADM-based system to screen for small molecules combinations that produced a collaborative effect on cardiomyocyte cycling and cytokinesi...

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Detalles Bibliográficos
Autores principales: Powers, Nevan, Huang, Guo N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072610/
https://www.ncbi.nlm.nih.gov/pubmed/35511305
http://dx.doi.org/10.1186/s13619-022-00120-z
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author Powers, Nevan
Huang, Guo N.
author_facet Powers, Nevan
Huang, Guo N.
author_sort Powers, Nevan
collection PubMed
description Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury. Du et al., reporting in Cell Stem Cell, employ a FUCCI- and MADM-based system to screen for small molecules combinations that produced a collaborative effect on cardiomyocyte cycling and cytokinesis. The authors generate a cocktail of five small molecules that increase cardiomyocyte proliferation and regeneration in vitro and in vivo with high efficiency, and explore its potential in cardiac regenerative repair after myocardial infarction through a new potential pathway for cardiomyocyte cell-cycle re-entry.
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spelling pubmed-90726102022-05-18 Mending a broken heart with novel cardiogenic small molecules Powers, Nevan Huang, Guo N. Cell Regen Research Highlight Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury. Du et al., reporting in Cell Stem Cell, employ a FUCCI- and MADM-based system to screen for small molecules combinations that produced a collaborative effect on cardiomyocyte cycling and cytokinesis. The authors generate a cocktail of five small molecules that increase cardiomyocyte proliferation and regeneration in vitro and in vivo with high efficiency, and explore its potential in cardiac regenerative repair after myocardial infarction through a new potential pathway for cardiomyocyte cell-cycle re-entry. Springer Nature Singapore 2022-05-05 /pmc/articles/PMC9072610/ /pubmed/35511305 http://dx.doi.org/10.1186/s13619-022-00120-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Highlight
Powers, Nevan
Huang, Guo N.
Mending a broken heart with novel cardiogenic small molecules
title Mending a broken heart with novel cardiogenic small molecules
title_full Mending a broken heart with novel cardiogenic small molecules
title_fullStr Mending a broken heart with novel cardiogenic small molecules
title_full_unstemmed Mending a broken heart with novel cardiogenic small molecules
title_short Mending a broken heart with novel cardiogenic small molecules
title_sort mending a broken heart with novel cardiogenic small molecules
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072610/
https://www.ncbi.nlm.nih.gov/pubmed/35511305
http://dx.doi.org/10.1186/s13619-022-00120-z
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