Interference with megalin expression/endocytic function by montelukast mitigates gentamicin nephrotoxicity: Downregulation of ClC-5 expression

Megalin receptor-mediated endocytosis participates a crucial role in gentamicin (GM) uptake, accumulation, and toxicity. In this study, we investigated the potential effects of montelukast (MLK) on megalin expression/endocytic function against GM nephrotoxicity. Male Wistar rats were administered GM...

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Detalles Bibliográficos
Autores principales: Azouz, Amany A., Hanna, Dina A., Abo-Saif, Ali A., Anwar Shehata Messiha, Basim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072701/
https://www.ncbi.nlm.nih.gov/pubmed/35528850
http://dx.doi.org/10.1016/j.jsps.2021.12.013

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