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Anticancer Properties of Curcumin Against Colorectal Cancer: A Review
Colorectal cancer (CRC) is one of the most common and reoccurring diseases, as well as the world’s second largest cause of mortality. Despite existing preventative, diagnostic, and treatment methods, such as chemotherapy, the number of instances rises year after year. As a result, new effective medi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072734/ https://www.ncbi.nlm.nih.gov/pubmed/35530318 http://dx.doi.org/10.3389/fonc.2022.881641 |
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author | Ojo, Oluwafemi Adeleke Adeyemo, Temiloluwa Rhoda Rotimi, Damilare Batiha, Gaber El-Saber Mostafa-Hedeab, Gomaa Iyobhebhe, Matthew Eboseremen Elebiyo, Tobiloba Christiana Atunwa, Bukola Ojo, Adebola Busola Lima, Clara Mariana Goncalves Conte-Junior, Carlos Adam |
author_facet | Ojo, Oluwafemi Adeleke Adeyemo, Temiloluwa Rhoda Rotimi, Damilare Batiha, Gaber El-Saber Mostafa-Hedeab, Gomaa Iyobhebhe, Matthew Eboseremen Elebiyo, Tobiloba Christiana Atunwa, Bukola Ojo, Adebola Busola Lima, Clara Mariana Goncalves Conte-Junior, Carlos Adam |
author_sort | Ojo, Oluwafemi Adeleke |
collection | PubMed |
description | Colorectal cancer (CRC) is one of the most common and reoccurring diseases, as well as the world’s second largest cause of mortality. Despite existing preventative, diagnostic, and treatment methods, such as chemotherapy, the number of instances rises year after year. As a result, new effective medications targeting specific checkpoints should be developed to combat CRC. Natural compounds, such as curcumin, have shown significant anti-colorectal cancer characteristics among medications that can be used to treat CRC. These chemicals are phenolic compounds that belong to the curcuminoids category. Curcumin exerts its anti-proliferative properties against CRC cell lines in vitro and in vivo via a variety of mechanisms, including the suppression of intrinsic and extrinsic apoptotic signaling pathways, the stoppage of the cell cycle, and the activation of autophagy. Curcumin also has anti-angiogenesis properties. Thus, this review is aimed at emphasizing the biological effect and mode of action of curcumin on CRC. Furthermore, the critical role of these substances in CRC chemoprevention was emphasized. |
format | Online Article Text |
id | pubmed-9072734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90727342022-05-07 Anticancer Properties of Curcumin Against Colorectal Cancer: A Review Ojo, Oluwafemi Adeleke Adeyemo, Temiloluwa Rhoda Rotimi, Damilare Batiha, Gaber El-Saber Mostafa-Hedeab, Gomaa Iyobhebhe, Matthew Eboseremen Elebiyo, Tobiloba Christiana Atunwa, Bukola Ojo, Adebola Busola Lima, Clara Mariana Goncalves Conte-Junior, Carlos Adam Front Oncol Oncology Colorectal cancer (CRC) is one of the most common and reoccurring diseases, as well as the world’s second largest cause of mortality. Despite existing preventative, diagnostic, and treatment methods, such as chemotherapy, the number of instances rises year after year. As a result, new effective medications targeting specific checkpoints should be developed to combat CRC. Natural compounds, such as curcumin, have shown significant anti-colorectal cancer characteristics among medications that can be used to treat CRC. These chemicals are phenolic compounds that belong to the curcuminoids category. Curcumin exerts its anti-proliferative properties against CRC cell lines in vitro and in vivo via a variety of mechanisms, including the suppression of intrinsic and extrinsic apoptotic signaling pathways, the stoppage of the cell cycle, and the activation of autophagy. Curcumin also has anti-angiogenesis properties. Thus, this review is aimed at emphasizing the biological effect and mode of action of curcumin on CRC. Furthermore, the critical role of these substances in CRC chemoprevention was emphasized. Frontiers Media S.A. 2022-04-22 /pmc/articles/PMC9072734/ /pubmed/35530318 http://dx.doi.org/10.3389/fonc.2022.881641 Text en Copyright © 2022 Ojo, Adeyemo, Rotimi, Batiha, Mostafa-Hedeab, Iyobhebhe, Elebiyo, Atunwa, Ojo, Lima and Conte-Junior https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Ojo, Oluwafemi Adeleke Adeyemo, Temiloluwa Rhoda Rotimi, Damilare Batiha, Gaber El-Saber Mostafa-Hedeab, Gomaa Iyobhebhe, Matthew Eboseremen Elebiyo, Tobiloba Christiana Atunwa, Bukola Ojo, Adebola Busola Lima, Clara Mariana Goncalves Conte-Junior, Carlos Adam Anticancer Properties of Curcumin Against Colorectal Cancer: A Review |
title | Anticancer Properties of Curcumin Against Colorectal Cancer: A Review |
title_full | Anticancer Properties of Curcumin Against Colorectal Cancer: A Review |
title_fullStr | Anticancer Properties of Curcumin Against Colorectal Cancer: A Review |
title_full_unstemmed | Anticancer Properties of Curcumin Against Colorectal Cancer: A Review |
title_short | Anticancer Properties of Curcumin Against Colorectal Cancer: A Review |
title_sort | anticancer properties of curcumin against colorectal cancer: a review |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072734/ https://www.ncbi.nlm.nih.gov/pubmed/35530318 http://dx.doi.org/10.3389/fonc.2022.881641 |
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