The Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context

Redox homeostasis is a lifelong pursuit of cancer cells. Depending on the context, reactive oxygen species (ROS) exert paradoxical effects on cancers; an appropriate concentration stimulates tumorigenesis and supports the progression of cancer cells, while an excessive concentration leads to cell de...

Descripción completa

Detalles Bibliográficos
Autores principales: Xing, Faliang, Hu, Qiangsheng, Qin, Yi, Xu, Jin, Zhang, Bo, Yu, Xianjun, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072740/
https://www.ncbi.nlm.nih.gov/pubmed/35530337
http://dx.doi.org/10.3389/fonc.2022.862743
_version_ 1784701126755483648
author Xing, Faliang
Hu, Qiangsheng
Qin, Yi
Xu, Jin
Zhang, Bo
Yu, Xianjun
Wang, Wei
author_facet Xing, Faliang
Hu, Qiangsheng
Qin, Yi
Xu, Jin
Zhang, Bo
Yu, Xianjun
Wang, Wei
author_sort Xing, Faliang
collection PubMed
description Redox homeostasis is a lifelong pursuit of cancer cells. Depending on the context, reactive oxygen species (ROS) exert paradoxical effects on cancers; an appropriate concentration stimulates tumorigenesis and supports the progression of cancer cells, while an excessive concentration leads to cell death. The upregulated antioxidant system in cancer cells limits ROS to a tumor-promoting level. In cancers, redox regulation interacts with tumor initiation, proliferation, metastasis, programmed cell death, autophagy, metabolic reprogramming, the tumor microenvironment, therapies, and therapeutic resistance to facilitate cancer development. This review discusses redox control and the major hallmarks of cancer.
format Online
Article
Text
id pubmed-9072740
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90727402022-05-07 The Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context Xing, Faliang Hu, Qiangsheng Qin, Yi Xu, Jin Zhang, Bo Yu, Xianjun Wang, Wei Front Oncol Oncology Redox homeostasis is a lifelong pursuit of cancer cells. Depending on the context, reactive oxygen species (ROS) exert paradoxical effects on cancers; an appropriate concentration stimulates tumorigenesis and supports the progression of cancer cells, while an excessive concentration leads to cell death. The upregulated antioxidant system in cancer cells limits ROS to a tumor-promoting level. In cancers, redox regulation interacts with tumor initiation, proliferation, metastasis, programmed cell death, autophagy, metabolic reprogramming, the tumor microenvironment, therapies, and therapeutic resistance to facilitate cancer development. This review discusses redox control and the major hallmarks of cancer. Frontiers Media S.A. 2022-04-22 /pmc/articles/PMC9072740/ /pubmed/35530337 http://dx.doi.org/10.3389/fonc.2022.862743 Text en Copyright © 2022 Xing, Hu, Qin, Xu, Zhang, Yu and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xing, Faliang
Hu, Qiangsheng
Qin, Yi
Xu, Jin
Zhang, Bo
Yu, Xianjun
Wang, Wei
The Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context
title The Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context
title_full The Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context
title_fullStr The Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context
title_full_unstemmed The Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context
title_short The Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context
title_sort relationship of redox with hallmarks of cancer: the importance of homeostasis and context
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072740/
https://www.ncbi.nlm.nih.gov/pubmed/35530337
http://dx.doi.org/10.3389/fonc.2022.862743
work_keys_str_mv AT xingfaliang therelationshipofredoxwithhallmarksofcancertheimportanceofhomeostasisandcontext
AT huqiangsheng therelationshipofredoxwithhallmarksofcancertheimportanceofhomeostasisandcontext
AT qinyi therelationshipofredoxwithhallmarksofcancertheimportanceofhomeostasisandcontext
AT xujin therelationshipofredoxwithhallmarksofcancertheimportanceofhomeostasisandcontext
AT zhangbo therelationshipofredoxwithhallmarksofcancertheimportanceofhomeostasisandcontext
AT yuxianjun therelationshipofredoxwithhallmarksofcancertheimportanceofhomeostasisandcontext
AT wangwei therelationshipofredoxwithhallmarksofcancertheimportanceofhomeostasisandcontext
AT xingfaliang relationshipofredoxwithhallmarksofcancertheimportanceofhomeostasisandcontext
AT huqiangsheng relationshipofredoxwithhallmarksofcancertheimportanceofhomeostasisandcontext
AT qinyi relationshipofredoxwithhallmarksofcancertheimportanceofhomeostasisandcontext
AT xujin relationshipofredoxwithhallmarksofcancertheimportanceofhomeostasisandcontext
AT zhangbo relationshipofredoxwithhallmarksofcancertheimportanceofhomeostasisandcontext
AT yuxianjun relationshipofredoxwithhallmarksofcancertheimportanceofhomeostasisandcontext
AT wangwei relationshipofredoxwithhallmarksofcancertheimportanceofhomeostasisandcontext

Ejemplares similares