SARS-CoV-2 variants – Evolution, spike protein, and vaccines

Despite the rising natural and vaccines mediated immunity, several countries have experienced a resurgence of the Coronavirus disease of 2019 (COVID-19) due to the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. From Alpha to Omicron, the variants of concern (VOC)...

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Detalles Bibliográficos
Autores principales: Chen, Kai-Wei K., Tsung-Ning Huang, Daniel, Huang, Li-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chang Gung University 2022
Materias:
Short Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072773/
https://www.ncbi.nlm.nih.gov/pubmed/35526825
http://dx.doi.org/10.1016/j.bj.2022.04.006
Descripción
Sumario:Despite the rising natural and vaccines mediated immunity, several countries have experienced a resurgence of the Coronavirus disease of 2019 (COVID-19) due to the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. From Alpha to Omicron, the variants of concern (VOC) have evolved several spike protein mutations that may have an impact on virus characteristics, such as transmissibility and antigenicity. In this review, we describe the evolution of SARS-CoV-2, summarize current knowledge of epidemiological and clinical features of the variants, and discuss the response strategies in terms of vaccines to reduce the burden of COVID-19.

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