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Anti-hypotensive effect of “Yahom Navakot” in rats with orthostatic hypotension

BACKGROUND AND AIM: Yahom Navakot (YN), is a Thai traditional medicine, consisting of 54 plants, for treating fainting and dizziness. Thus, YN might relieve orthostatic hypotension (OH) symptoms, but its therapeutic action is unclear. Therefore, this study evaluated YN in OH rats, using a head-up ti...

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Autores principales: Inchan, Anjaree, Pathomwichaiwat, Thanika, Bualeong, Tippaporn, Tipratchadaporn, Sasipong, Chootip, Krongkarn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072801/
https://www.ncbi.nlm.nih.gov/pubmed/35528473
http://dx.doi.org/10.1016/j.jtcme.2021.08.002
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author Inchan, Anjaree
Pathomwichaiwat, Thanika
Bualeong, Tippaporn
Tipratchadaporn, Sasipong
Chootip, Krongkarn
author_facet Inchan, Anjaree
Pathomwichaiwat, Thanika
Bualeong, Tippaporn
Tipratchadaporn, Sasipong
Chootip, Krongkarn
author_sort Inchan, Anjaree
collection PubMed
description BACKGROUND AND AIM: Yahom Navakot (YN), is a Thai traditional medicine, consisting of 54 plants, for treating fainting and dizziness. Thus, YN might relieve orthostatic hypotension (OH) symptoms, but its therapeutic action is unclear. Therefore, this study evaluated YN in OH rats, using a head-up tilt test (HUT). EXPERIMENTAL PROCEDURE: Rats were anesthetized, and OH induced via a 90(o)HUT, before and after administering vehicle, a YN powder suspension (10, 100 mg/kg), a YN aqueous extract (100 mg/kg), and midodrine (5 mg/kg). The systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), pulse pressure (PP) and heart rate (HR) were determined via the carotid artery. Plasma noradrenaline (NA) was evaluated. YN-induced vasoconstriction of isolated rat aorta rings was determined using organ bath technique. RESULTS AND CONCLUSION: Baseline BP increased with the 100 mg/kg YN powder suspension, the YN aqueous extract or midodrine, while HR decreased, compared with vehicle and control. 90(o)HUT rapidly reduced SBP, DPB and MAP, but increased HR, for control and vehicle-treated groups, but BP was steady with the 100 mg/kg YN powder suspension, the YN aqueous extract or midodrine. The 90(o)HUT-increase in HR was most pronounced with the 100 mg/kg YN powder suspension (the traditional formulation). This accords with increased plasma NA. YN also induced vasoconstriction in rat aorta via α(1)-receptor activation. Thus, the anti-hypotensive action of YN involved a stimulating effect on the heart and blood vessels via sympathetic activation. The results support the traditional use of YN and demonstrated the effectiveness of YN for OH prevention.
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spelling pubmed-90728012022-05-07 Anti-hypotensive effect of “Yahom Navakot” in rats with orthostatic hypotension Inchan, Anjaree Pathomwichaiwat, Thanika Bualeong, Tippaporn Tipratchadaporn, Sasipong Chootip, Krongkarn J Tradit Complement Med Article BACKGROUND AND AIM: Yahom Navakot (YN), is a Thai traditional medicine, consisting of 54 plants, for treating fainting and dizziness. Thus, YN might relieve orthostatic hypotension (OH) symptoms, but its therapeutic action is unclear. Therefore, this study evaluated YN in OH rats, using a head-up tilt test (HUT). EXPERIMENTAL PROCEDURE: Rats were anesthetized, and OH induced via a 90(o)HUT, before and after administering vehicle, a YN powder suspension (10, 100 mg/kg), a YN aqueous extract (100 mg/kg), and midodrine (5 mg/kg). The systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), pulse pressure (PP) and heart rate (HR) were determined via the carotid artery. Plasma noradrenaline (NA) was evaluated. YN-induced vasoconstriction of isolated rat aorta rings was determined using organ bath technique. RESULTS AND CONCLUSION: Baseline BP increased with the 100 mg/kg YN powder suspension, the YN aqueous extract or midodrine, while HR decreased, compared with vehicle and control. 90(o)HUT rapidly reduced SBP, DPB and MAP, but increased HR, for control and vehicle-treated groups, but BP was steady with the 100 mg/kg YN powder suspension, the YN aqueous extract or midodrine. The 90(o)HUT-increase in HR was most pronounced with the 100 mg/kg YN powder suspension (the traditional formulation). This accords with increased plasma NA. YN also induced vasoconstriction in rat aorta via α(1)-receptor activation. Thus, the anti-hypotensive action of YN involved a stimulating effect on the heart and blood vessels via sympathetic activation. The results support the traditional use of YN and demonstrated the effectiveness of YN for OH prevention. Elsevier 2021-08-03 /pmc/articles/PMC9072801/ /pubmed/35528473 http://dx.doi.org/10.1016/j.jtcme.2021.08.002 Text en © 2021 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Inchan, Anjaree
Pathomwichaiwat, Thanika
Bualeong, Tippaporn
Tipratchadaporn, Sasipong
Chootip, Krongkarn
Anti-hypotensive effect of “Yahom Navakot” in rats with orthostatic hypotension
title Anti-hypotensive effect of “Yahom Navakot” in rats with orthostatic hypotension
title_full Anti-hypotensive effect of “Yahom Navakot” in rats with orthostatic hypotension
title_fullStr Anti-hypotensive effect of “Yahom Navakot” in rats with orthostatic hypotension
title_full_unstemmed Anti-hypotensive effect of “Yahom Navakot” in rats with orthostatic hypotension
title_short Anti-hypotensive effect of “Yahom Navakot” in rats with orthostatic hypotension
title_sort anti-hypotensive effect of “yahom navakot” in rats with orthostatic hypotension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072801/
https://www.ncbi.nlm.nih.gov/pubmed/35528473
http://dx.doi.org/10.1016/j.jtcme.2021.08.002
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