Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors

Sulfotransferases (STs) catalyse the transfer of a sulfonyl group (‘sulfation’) from the enzyme co-factor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to a variety of biomolecules. Tyrosine sulfation of proteins and carbohydrate sulfation play a crucial role in many protein–protein interactions and...

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Detalles Bibliográficos
Autores principales: Kershaw, Neil M., Byrne, Dominic P., Parsons, Hollie, Berry, Neil G., Fernig, David G., Eyers, Patrick A., Cosstick, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072872/
https://www.ncbi.nlm.nih.gov/pubmed/35530783
http://dx.doi.org/10.1039/c9ra07567d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072872/
https://www.ncbi.nlm.nih.gov/pubmed/35530783
http://dx.doi.org/10.1039/c9ra07567d

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