Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA

Porous silicon nanoparticles as a novel platform in gene therapy, have shown to be an efficient vehicle for the delivery of nucleic acids in cells. For the first time, a family of porous silicon nanoparticles has been produced featuring an amino-acid functionalized cationic external surface aiming a...

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Detalles Bibliográficos
Autores principales: Chaix, Arnaud, Cueto-Diaz, Eduardo, Delalande, Anthony, Knezevic, Nikola, Midoux, Patrick, Durand, Jean-Olivier, Pichon, Chantal, Cunin, Frederique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072902/
https://www.ncbi.nlm.nih.gov/pubmed/35530795
http://dx.doi.org/10.1039/c9ra05461h
Descripción
Sumario:Porous silicon nanoparticles as a novel platform in gene therapy, have shown to be an efficient vehicle for the delivery of nucleic acids in cells. For the first time, a family of porous silicon nanoparticles has been produced featuring an amino-acid functionalized cationic external surface aiming at pDNA complexation. The amino acid-based pDNA nanocarriers, displaying an average diameter of 295 nm, succeeded in transfection of HEK293 cells with an efficiency 300 times superior to “bare” porous silicon nanoparticles.

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